Recent advances in understanding and diagnosing hepatitis B virus infection

被引：4
作者：
Fourati, Slim [1 ,2 ]
Pawlotsky, Jean-Michel [1 ,2 ]
机构：
[1] Univ Paris Est, Hop Henri Mondor, Ctr Natl Reference Hepatites Virales B C & Delta, Serv Virol, 51 Ave Mal de Lattre de Tassigny, F-94010 Creteil, France
[2] INSERM, U955, 51 Ave Mal de Lattre de Tassigny, F-94010 Creteil, France
来源：
VIROLOGIE | 2019年 / 23卷 / 01期
关键词：
hepatitis B; HBV RNA; HBcrAg; HBsAg quantification; CORE-RELATED ANTIGEN; CLOSED CIRCULAR DNA; NUCLEOS(T)IDE ANALOG THERAPY; SERUM HBV PGRNA; SURFACE-ANTIGEN; NATURAL-HISTORY; HEPATOCELLULAR-CARCINOMA; HBSAG QUANTIFICATION; ANTIVIRAL TREATMENT; VIRAL-HEPATITIS;
D O I：
10.1684/vir.2019.0760
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
HepatitisBvirus (HBV) infects approximately 257 million individuals worldwide. Recent advances in the virology and diagnosis of HBV infection are summarized in this review article. A novel classification of the different phases of chronic HBV infection, proposed by the European Association for the Study of the Liver (EASL), is presented. New diagnostic and monitoring tools are now available, including rapid diagnostic tests for hepatitisBsurface antigen (HBsAg) detection, HBsAg quantification assays, an HBV core-related antigen (HBcrAg) quantification test, and HBV RNA quantification testing. Their clinical utility under study is discussed in this review.
引用
收藏
页码：23 / 34
页数：12
相关论文
共 79 条
  • [21] Global HBV burden: guesstimates and facts
    Ginzberg, Dina
    Wong, Robert J.
    Gish, Robert
    [J]. HEPATOLOGY INTERNATIONAL, 2018, 12 (04) : 315 - 329
  • [22] DUCK HEPATITIS-B VIRUS INTEGRATIONS IN LMH CHICKEN HEPATOMA-CELLS - IDENTIFICATION AND CHARACTERIZATION OF NEW EPISOMALLY DERIVED INTEGRATIONS
    GONG, SS
    JENSEN, AD
    WANG, HP
    ROGLER, CE
    [J]. JOURNAL OF VIROLOGY, 1995, 69 (12) : 8102 - 8108
  • [23] Graber-Stiehl I, 2018, NATURE, V564, P24, DOI 10.1038/d41586-018-07592-7
  • [24] Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma
    Honda, Masao
    Shirasaki, Takayoshi
    Terashima, Takeshi
    Kawaguchi, Kazunori
    Nakamura, Mikiko
    Oishi, Naoki
    Wang, Xuyang
    Shimakami, Tetsuro
    Okada, Hikari
    Arai, Kuniaki
    Yamashita, Taro
    Sakai, Yoshio
    Yamashita, Tatsuya
    Mizukoshi, Eishiro
    Kaneko, Shuichi
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2016, 213 (07) : 1096 - 1106
  • [25] HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy
    Hosaka, Tetsuya
    Suzuki, Fumitaka
    Kobayashi, Masahiro
    Hirakawa, Miharu
    Kawamura, Yusuke
    Yatsuji, Hiromi
    Sezaki, Hitomi
    Akuta, Norio
    Suzuki, Yoshiyuki
    Saitoh, Satoshi
    Arase, Yasuji
    Ikeda, Kenji
    Kobayashi, Mariko
    Kumada, Hiromitsu
    [J]. LIVER INTERNATIONAL, 2010, 30 (10) : 1461 - 1470
  • [26] The prognosis and management of inactive HBV carriers
    Invernizzi, Federica
    Vigano, Mauro
    Grossi, Glenda
    Lampertico, Pietro
    [J]. LIVER INTERNATIONAL, 2016, 36 : 100 - 104
  • [27] Clinical outcomes and predictors for relapse after cessation of oral antiviral treatment in chronic hepatitis B patients
    Jung, Kyu Sik
    Park, Jun Yong
    Chon, Young Eun
    Kim, Hyon-Suk
    Kang, Wonseok
    Kim, Beom Kyung
    Kim, Seung Up
    Kim, Do Young
    Han, Kwang-Hyub
    Ahn, Sang Hoon
    [J]. JOURNAL OF GASTROENTEROLOGY, 2016, 51 (08) : 830 - 839
  • [28] Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus
    Kitamura, Kouichi
    Que, Lusheng
    Shimadu, Miyuki
    Koura, Miki
    Ishihara, Yuuki
    Wakae, Kousho
    Nakamura, Takashi
    Watashi, Koichi
    Wakita, Takaji
    Muramatsu, Masamichi
    [J]. PLOS PATHOGENS, 2018, 14 (06)
  • [29] Kock J, 1996, HEPATOLOGY, V23, P405
  • [30] Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
    Koeniger, Christian
    Wingert, Ida
    Marsmann, Moritz
    Roesler, Christine
    Beck, Juergen
    Nassal, Michael
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (40) : E4244 - E4253
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