The Studies on Pharmacophore Model of K+ Channel Opener

被引：1
|
作者：
Chen Hongming [1 ]
Zhou Jiaju [1 ]
Xie Guirong [1 ]
Pang Suhua [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem Met, Lab Comp Chemostry, Beijing 100080, Peoples R China
来源：
ACTA PHYSICO-CHIMICA SINICA | 1997年 / 13卷 / 02期
关键词：
K+ channel opener; CoMFA; Pharmacophore model; QSAR;
D O I：
10.3866/PKU.WHXB19970202
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this paper, a set of ATP sensitive K+ channel openers (KCO) whose structure are different, were investigated with the aim to develope our previously defined KCO's pharmacophore model.To validate the effectiveness of the pharmacophore model, A Comparative molecule field analysis (CoMFA) was proceeded, aligning the molecules according to the requirement of the model, and good results were obtained. This pharmacophore model may be a start point to design new KCO compounds.
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页码：101 / 105
页数：5
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