Plasma indoxyl sulfate levels predict cardiovascular events in patients with mild chronic heart failure

被引：27

作者：

Imazu, Miki ^{[1
]}

Fukuda, Hiroki ^{[1
]}

Kanzaki, Hideaki ^{[2
]}

Amaki, Makoto ^{[2
]}

Hasegawa, Takuya ^{[2
]}

Takahama, Hiroyuki ^{[2
]}

Hitsumoto, Tatsuro ^{[1
]}

Tsukamoto, Osamu ^{[3
]}

Morita, Toshisuke ^{[4
]}

Ito, Shin ^{[1
]}

Kitakaze, Masafumi ^{[1
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Dept Clin Res & Dev, 6-1 Kishibe Shimmachi, Suita, Osaka 5648565, Japan

[2] Natl Cerebral & Cardiovasc Ctr, Dept Cardiovasc Med, 6-1 Kishibe Shimmachi, Suita, Osaka, Japan

[3] Osaka Univ, Grad Sch Med, Dept Med Biochem, 2-2 Yamadaoka, Suita, Osaka, Japan

[4] Toho Univ, Omori Med Ctr, Dept Lab Med, Tokyo, Japan

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

ORGANIC ANION TRANSPORTERS; CHRONIC KIDNEY-DISEASE; BOUND UREMIC TOXINS; NF-KAPPA-B; KLOTHO EXPRESSION; ORAL SORBENT; DYSFUNCTION; PROGRESSION; ACTIVATION; AST-120;

D O I：

10.1038/s41598-020-73633-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Indoxyl sulfate (IS) is associated with either chronic kidney disease or renal failure, which may predict cardiovascular events via cardiorenal syndrome. The present study aimed to elucidate whether the plasma levels of IS can predict the occurrence of cardiovascular events in patients with chronic heart failure (CHF) and investigate which causes of CHF leading to cardiovascular events are highly influenced by plasma IS levels. We measured the plasma IS levels in 165 patients with CHF [valvular disease: 78, dilated cardiomyopathy: 29, hypertrophic cardiomyopathy (HCM): 25 and others: 33] admitted to our hospital in 2012, and we followed up these patients for more than 5 years (the median follow-up period: 5.3 years). We measured the plasma IS level in 165 patients with CHF, and Kaplan-Meier analyses showed that high plasma IS levels (>= 0.79 mu g/mL, the median value) could predict the occurrence of cardiovascular events, i.e., cardiovascular death or rehospitalization due to the worsening of CHF. The sub-analyses showed that the high IS level could predict cardiovascular events in patients with CHF due to HCM and that the plasma IS levels were closely associated with left ventricular (LV) dimension, LV systolic dysfunction, and plasma B-type natriuretic peptide levels, rather than LV diastolic dysfunction. Plasma IS level predicts cardiovascular events in patients with CHF, especially those with HCM along with cardiac dysfunction. Besides, IS may become a proper biomarker to predict cardiovascular events in patients with CHF.

引用

页数：7

共 29 条

[1] An Oral Sorbent, AST-120, Increases Klotho Expression and Inhibits Cell Senescence in the Kidney of Uremic Rats [J].