Molecular epidemiology of serotype 19A Streptococcus pneumoniae among invasive isolates from Alaska, 1986-2010

被引:11
作者
Rudolph, Karen
Bruce, M. G.
Bulkow, L.
Zulz, T.
Reasonover, A.
Harker-Jones, M.
Hurlburt, D.
Hennessy, T. W.
机构
[1] Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC)
关键词
Streptococcus pneumoniae; serotype; 19A; MLST; invasive disease; Alaska; PNEUMOCOCCAL CONJUGATE VACCINE; ANTIMICROBIAL RESISTANCE; UNITED-STATES; POPULATION SNAPSHOT; GENETIC-STRUCTURE; DISEASE; CHILDREN; MASSACHUSETTS; REPLACEMENT; EMERGENCE;
D O I
10.3402/ijch.v72i0.20854
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background. After the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Alaska, the incidence of invasive pneumococcal disease (IPD) due to non-vaccine serotypes, particularly serotype 19A, increased. The aim of this study was to describe the molecular epidemiology of IPD due to serotype 19A in Alaska. Methods. IPD data were collected from 1986 to 2010 through population-based laboratory surveillance. Isolates were serotyped by the Quellung reaction and MICs determined by broth microdilution. Genotypes were assessed by multilocus sequence typing. Results. Among 3,294 cases of laboratory-confirmed IPD, 2,926 (89%) isolates were available for serotyping, of which 233 (8%) were serotype 19A. Across all ages, the proportion of IPD caused by serotype 19A increased from 3.5% (63/1823) pre-PCV7 (1986-2000) to 15.4% (170/1103) post-PCV7 (2001-2010) (p<0.001); among children <5 years of age, the proportion increased from 5.0% (39/776) to 33.0% (76/230) (p<0.001). The annual incidence rate of IPD due to serotype 19A (all ages) increased from 0.73 cases pre-PCV7 to 2.56 cases/100,000 persons post-PCV7 (p<0.001); rates among children <5 years of age increased from 4.84 cases to 14.1 cases/100,000 persons (p<0.001). Among all IPD isolates with reduced susceptibility to penicillin, 17.8% (32/180) were serotype 19A pre-PCV7 and 64% (121/189) were serotype 19A post-PCV7 (p<0.001). Eighteen different sequence types (STs) were identified; ST199 or single locus variants of ST199 (n=150) and ST172 (n=59) accounted for the majority of isolates. Multidrug-resistant isolates were clustered in ST199 and ST320. Conclusion. While PCV13 should significantly reduce the burden of disease due to 19A, these data highlight the need to continue surveillance for IPD to monitor the effects of vaccination on the expansion and emergence of non-PCV strains.
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页码:611 / 617
页数:7
相关论文
共 35 条
  • [1] [Anonymous], 2004, PEDIATRICS
  • [2] [Anonymous], 8 INT S PNEUM PNEUM
  • [3] Emergence of a multidrug-resistant clone (ST320) among invasive serotype 19A pneumococci in Spain
    Ardanuy, Carmen
    Rolo, Dora
    Fenoll, Asuncion
    Tarrago, David
    Calatayud, Laura
    Linares, Josefina
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 64 (03) : 507 - 510
  • [4] Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002
    Beall, B
    McEllistrem, MC
    Gertz, RE
    Wedel, S
    Boxrud, DJ
    Gonzalez, AL
    Medina, MJ
    Pai, R
    Thompson, TA
    Harrison, LH
    McGee, L
    Whitney, CG
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (03) : 999 - 1017
  • [5] Shifting Genetic Structure of Invasive Serotype 19A Pneumococci in the United States
    Beall, Bernard W.
    Gertz, Robert E.
    Hulkower, Rachel L.
    Whitney, Cynthia G.
    Moore, Matthew R.
    Brueggemann, Angela B.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (10) : 1360 - 1368
  • [6] Streptococcus pneumoniae serotype 19A in children, South Korea
    Choi, Eun Hwa
    Kim, So Hee
    Eun, Byung Wook
    Kim, Sun Jung
    Kim, Nam Hee
    Lee, Jina
    Lee, Hoan Jong
    [J]. EMERGING INFECTIOUS DISEASES, 2008, 14 (02) : 275 - 281
  • [7] Serotypes and sequence types of pneumococci causing invasive disease in Scotland prior to the introduction of pneumococcal conjugate polysaccharide vaccines
    Clarke, SC
    Scott, KJ
    McChlery, SM
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (10) : 4449 - 4452
  • [8] Clinical and Laboratory Standards Institute, 2007, APPROVED STANDARD M1
  • [9] Introduction and Proliferation of Multidrug-Resistant Streptococcus pneumoniae Serotype 19A Clones That Cause Acute Otitis Media in an Unvaccinated Population
    Dagan, Ron
    Givon-Lavi, Noga
    Leibovitz, Eugene
    Greenberg, David
    Porat, Nurith
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (06) : 776 - 785
  • [10] THE EPIDEMIOLOGY OF INVASIVE PNEUMOCOCCAL DISEASE IN ALASKA, 1986-1990 - ETHNIC-DIFFERENCES AND OPPORTUNITIES FOR PREVENTION
    DAVIDSON, M
    PARKINSON, AJ
    BULKOW, LR
    FITZGERALD, MA
    PETERS, HV
    PARKS, DJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (02) : 368 - 376