Ultrafast 2D NMR on a benchtop spectrometer: Applications and perspectives

被引：60

作者：

Gouilleux, Boris ^{[1
]}

Charrier, Benoit ^{[1
]}

Akoka, Serge ^{[1
]}

Felpin, Francois-Xavier ^{[1
,2
]}

Rodriguez-Zubiri, Mireia ^{[1
]}

Giraudeau, Patrick ^{[1
,2
]}

机构：

[1] Fac Sci, Chim & Interdisciplinarite Synth Anal Modelisat C, UMR 6230, BP 92208,2 Rue Houssiniere, F-44322 Nantes 03, France

[2] Inst Univ France, 1 Rue Descartes, F-75005 Paris, France

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2016年 / 83卷

关键词：

Benchtop NMR; Multi-dimensional NMR; Ultrafast; low-field NMR; Real-time monitoring; Edible oil; Screening; NUCLEAR-MAGNETIC-RESONANCE; MHZ H-1-NMR SPECTROSCOPY; CANCER-CELL-EXTRACTS; VIRGIN OLIVE OIL; MULTIDIMENSIONAL NMR; SINGLE SCAN; SENSITIVITY; AUTHENTICATION; SPECTRA;

D O I：

10.1016/j.trac.2016.01.014

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Benchtop NMR spectrometers are associated with significant resolution losses, as peak overlaps become ubiquitous at low field. 2D spectroscopy offers an appealing solution to this issue. However 2D NMR is associated with long experimental times which are ill-suited for high-throughput applications such as real-time reaction monitoring or rapid screening. The first implementation of ultrafast (UF) 2D NMR on a benchtop spectrometer-including BO gradients- was recently reported, making it possible to record 2D spectra in a single -or at most a few-scans. In the present review, we investigate the analytical performance of UF 2D NMR at low field (43 MHz) and its application potential in two complementary research fields: real-time reaction monitoring and rapid screening. UF 2D spectroscopy at low field appears to be a powerful complement to existing analytical methods, and paves the way towards a number of developments in the field of spatially-encoded NMR at low field. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：65 / 75

页数：11

共 49 条

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