Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections

被引：231

作者：

Coakley, Gillian ^{[1
,2
]}

Maizels, Rick M. ^{[1
,2
]}

Buck, Amy H. ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Sch Biol Sci, Inst Immunol & Infect Res, Edinburgh EH9 3FL, Midlothian, Scotland

[2] Univ Edinburgh, Sch Biol Sci, Ctr Immun Infect & Evolut, Edinburgh EH9 3FL, Midlothian, Scotland

来源：

TRENDS IN PARASITOLOGY | 2015年 / 31卷 / 10期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

TRYPANOSOMA-CRUZI; DENDRITIC CELLS; TRANSFERRIN RECEPTOR; PROTECTIVE IMMUNITY; PROTEOMIC ANALYSIS; HELMINTH DISEASES; RESEARCH AGENDA; IN-VITRO; LEISHMANIA; PROTEIN;

D O I：

10.1016/j.pt.2015.06.009

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Extracellular vesicles (EVs) have emerged as a ubiquitous mechanism for transferring information between cells and organisms across all three kingdoms of life. In addition to their roles in normal physiology, vesicles also transport molecules from pathogens to hosts and can spread antigens as well as infectious agents. Although initially described in the host-pathogen context for their functions in immune surveillance, vesicles enable multiple modes of communication by, and between, parasites. Here we review the literature demonstrating that EVs are secreted by intracellular and extracellular eukaryotic parasites, as well as their hosts, and detail the functional properties of these vesicles in maturation, pathogenicity and survival. We further describe the prospects for targeting or exploiting these complexes in therapeutic and vaccine strategies.

引用

页码：477 / 489

页数：13

共 85 条

[1] Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice [J].

Aswad, Hala ;

Forterre, Alexis ;

Wiklander, Oscar P. B. ;

Vial, Guillaume ;

Danty-Berger, Emmanuelle ;

Jalabert, Audrey ;

Lamaziere, Antonin ;

Meugnier, Emmanuelle ;

Pesenti, Sandra ;

Ott, Catherine ;

Chikh, Karim ;

El-Andaloussi, Samir ;

Vidal, Hubert ;

Lefai, Etienne ;

Rieusset, Jennifer ;

Rome, Sophie .

DIABETOLOGIA, 2014, 57 (10) :2155-2164

[2] Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion [J].

Atay, Safinur ;

Banskota, Samagya ;

Crow, Jennifer ;

Sethi, Geetika ;

Rink, Lori ;

Godwin, Andrew K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (02) :711-716

[3] Proteomic Analysis of Trypanosoma cruzi Secretome: Characterization of Two Populations of Extracellular Vesicles and Soluble Proteins [J].

Bayer-Santos, Ethel ;

Aguilar-Bonavides, Clemente ;

Rodrigues, Silas Pessini ;

Cordero, Esteban Mauricio ;

Marques, Alexandre Ferreira ;

Varela-Ramirez, Armando ;

Choi, Hyungwon ;

Yoshida, Nobuko ;

da Silveira, Jose Franco ;

Almeida, Igor C. .

JOURNAL OF PROTEOME RESEARCH, 2013, 12 (02) :883-897

[4] A vaccine based on exosomes secreted by a dendritic cell line confers protection against T. gondii infection in syngeneic and allogeneic mice [J].

Beauvillain, Celine ;

Ruiz, Sophie ;

Guiton, Rachel ;

Bout, Daniel ;

Dimier-Poisson, Isabelle .

MICROBES AND INFECTION, 2007, 9 (14-15) :1614-1622

[5] Exosomes are an effective vaccine against congenital toxoplasmosis in mice [J].

Beauvillain, Celine ;

Juste, Matthieu O. ;

Dion, Sarah ;

Pierre, Josette ;

Dimier-Poisson, Isabelle .

VACCINE, 2009, 27 (11) :1750-1757

[6]

Bemal D., 2014, J PROTEOMICS, V105, P232

[7] Augmented plasma microparticles during acute Plasmodium vivax infection [J].

Campos, Fernanda M. F. ;

Franklin, Bernardo S. ;

Teixeira-Carvalho, Andrea ;

Filho, Agnaldo L. S. ;

de Paula, Salua C. O. ;

Fontes, Cor J. ;

Brito, Cristiana F. ;

Carvalho, Luzia H. .

MALARIA JOURNAL, 2010, 9

[8] Inefficient Complement System Clearance of Trypanosoma cruzi Metacyclic Trypomastigotes Enables Resistant Strains to Invade Eukaryotic Cells [J].

Cestari, Igor ;

Ramirez, Marcel I. .

PLOS ONE, 2010, 5 (03)

[9] Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype [J].

Chaiyadet, Sujittra ;

Sotillo, Javier ;

Smout, Michael ;

Cantacessi, Cinzia ;

Jones, Malcolm K. ;

Johnson, Michael S. ;

Turnbull, Lynne ;

Whitchurch, Cynthia B. ;

Potriquet, Jeremy ;

Laohaviroj, Marut ;

Mulvenna, Jason ;

Brindley, Paul J. ;

Bethony, Jeffrey M. ;

Laha, Thewarach ;

Sripa, Banchob ;

Loukas, Alex .

JOURNAL OF INFECTIOUS DISEASES, 2015, 212 (10) :1636-1645

[10] Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells [J].

Chalmin, Fanny ;

Ladoire, Sylvain ;

Mignot, Gregoire ;

Vincent, Julie ;

Bruchard, Melanie ;

Remy-Martin, Jean-Paul ;

Boireau, Wilfrid ;

Rouleau, Alain ;

Simon, Benoit ;

Lanneau, David ;

De Thonel, Aurelie ;

Multhoff, Gabriele ;

Hamman, Arlette ;

Martin, Francois ;

Chauffert, Bruno ;

Solary, Eric ;

Zitvogel, Laurence ;

Garrido, Carmen ;

Ryffel, Bernhard ;

Borg, Christophe ;

Apetoh, Lionel ;

Rebe, Cedric ;

Ghiringhelli, Francois .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (02) :457-471

← 1 2 3 4 5 6 7 8 9 →