Control of Human Viral Infections by Natural Killer Cells

被引：327

作者：

Jost, Stephanie ^{[1
]}

Altfeld, Marcus

机构：

[1] MIT, Ragon Inst MGH, Boston, MA 02129 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 | 2013年 / 31卷

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

HIV-1; HCV; influenza; CMV; KIR; NKG2D; NK cells; HEPATITIS-C-VIRUS; IMMUNOGLOBULIN-LIKE RECEPTORS; COMPLEX CLASS-I; HUMAN CYTOMEGALOVIRUS-INFECTION; EXPOSED UNINFECTED INDIVIDUALS; ACUTE HIV-1 INFECTION; CD8(+) T-CELLS; HUMAN NK CELLS; INFLUENZA-VIRUS; INHIBITORY RECEPTOR;

D O I：

10.1146/annurev-immunol-032712-100001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are effector cells of the innate immune system and are important in the control of viral infections. Their relevance is reflected by the multiple mechanisms evolved by viruses to evade NK cell-mediated immune responses. Over recent years, our understanding of the interplay between NK cell immunity and viral pathogenesis has improved significantly. Here, we review the role of NK cells in the control of four important viral infections in humans: cytomegalovirus, influenza virus, HIV-1, and hepatitis C virus.

引用

收藏

页码：163 / 194

页数：32

相关论文

共 212 条

[1] Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice [J].

Abdul-Careem, Mohamed F. ;

Mian, M. Firoz ;

Yue, Geoffry ;

Gillgrass, Amy ;

Chenoweth, Meghan J. ;

Barra, Nicole G. ;

Chew, Marianne V. ;

Chan, Tiffany ;

Al-Garawi, Amal A. ;

Jordana, Manel ;

Ashkar, Ali A. .

JOURNAL OF INFECTIOUS DISEASES, 2012, 206 (02) :167-177

[2] Enhanced recognition of human NK receptors after influenza virus infection [J].

Achdout, H ;

Arnon, TI ;

Markel, G ;

Gonen-Gross, T ;

Lieberman, N ;

Gazit, R ;

Joseph, A ;

Kedar, E ;

Mandelboim, O .

JOURNAL OF IMMUNOLOGY, 2003, 171 (02) :915-923

[3] Influenza virus infection augments NK cell inhibition through reorganization of major histocompatibility complex class I proteins [J].

Achdout, Hagit ;

Manaster, Irit ;

Mandelboim, Ofer .

JOURNAL OF VIROLOGY, 2008, 82 (16) :8030-8037

[4] Killing of Avian and Swine Influenza Virus by Natural Killer Cells [J].

Achdout, Hagit ;

Meningher, Tal ;

Hirsh, Shira ;

Glasner, Ariella ;

Bar-On, Yotam ;

Gur, Chamutal ;

Porgador, Angel ;

Mendelson, Michal ;

Mandelboim, Michal ;

Mandelboim, Ofer .

JOURNAL OF VIROLOGY, 2010, 84 (08) :3993-4001

[5] Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses [J].

Ahlenstiel, Golo ;

Martin, Maureen P. ;

Gao, Xiaojiang ;

Carrington, Mary ;

Rehermann, Barbara .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (03) :1017-1026

[6] Natural Killer Cells Are Polarized Toward Cytotoxicity in Chronic Hepatitis C in an Interferon-Alfa-Dependent Manner [J].

Ahlenstiel, Golo ;

Titerence, Rachel H. ;

Koh, Christopher ;

Edlich, Birgit ;

Feld, Jordan J. ;

Rotman, Yaron ;

Ghany, Marc G. ;

Hoofnagle, Jay H. ;

Liang, T. Jake ;

Heller, Theo ;

Rehermann, Barbara .

GASTROENTEROLOGY, 2010, 138 (01) :325-335

[7] Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection [J].

Alter, G ;

Teigen, N ;

T Davis, B ;

Addo, MM ;

Suscovich, TJ ;

Waring, MT ;

Streeck, H ;

Johnston, MN ;

Staller, KD ;

Zaman, MT ;

Yu, XG ;

Lichterfeld, M ;

Basgoz, N ;

Rosenberg, ES ;

Altfeld, M .

BLOOD, 2005, 106 (10) :3366-3369

[8] Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes [J].

Alter, Galit ;

Martin, Maureen P. ;

Teigen, Nickolas ;

Carr, William H. ;

Suscovich, Todd J. ;

Schneidewind, Arne ;

Streeck, Hendrik ;

Waring, Michael ;

Meier, Angela ;

Brander, Christian ;

Lifson, Jeffrey D. ;

Allen, Todd M. ;

Carrington, Mary ;

Altfeld, Marcus .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (12) :3027-3036

[9] Evolution of innate and adaptive effector cell functions during acute HIV-1 infection [J].

Alter, Galit ;

Teigen, Nickolas ;

Ahern, Ryan ;

Streeck, Hendrik ;

Meier, Angela ;

Rosenberg, Eric S. ;

Altfeld, Marcus .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (10) :1452-1460

[10] HIV-1 adaptation to NK-cell-mediated immune pressure [J].

Alter, Galit ;

Heckerman, David ;

Schneidewind, Arne ;

Fadda, Lena ;

Kadie, Carl M. ;

Carlson, Jonathan M. ;

Oniangue-Ndza, Cesar ;

Martin, Maureen ;

Li, Bin ;

Khakoo, Salim I. ;

Carrington, Mary ;

Allen, Todd M. ;

Altfeld, Marcus .

NATURE, 2011, 476 (7358) :96-+

← 1 2 3 4 5 6 7 8 9 10 →