Rhodium-Catalyzed Asymmetric Cyclization/Addition Reactions of 1,6-Enynes and Oxa/Azabenzonorbornadienes

被引：22

作者：

Zhou, Yongyun ^{[1
]}

Yu, Lu ^{[1
]}

Chen, Jingchao ^{[1
]}

Xu, Jianbin ^{[1
]}

He, Zhenxiu ^{[1
]}

Shen, Guoli ^{[1
]}

Fan, Baomin ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 05期

基金：

中国国家自然科学基金;

关键词：

RING-OPENING REACTIONS; 2+2 CYCLOADDITION; BICYCLIC ALKENES; ENZYMATIC DESYMMETRISATION; TERMINAL ALKYNES; OXABENZONORBORNADIENES; AZABENZONORBORNADIENES; CYCLOISOMERIZATION; HYDROALKYNYLATION; (+)-HOMOCHELIDONINE;

D O I：

10.1021/acs.orglett.7b04044

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild, efficient, and novel rhodium catalyzed asymmetric cyclization addition domino reaction of oxa/azabenzonorbornadienes and 1,6-enynes is documented. Through the use of a [Rh(COD)(2)]BF4-(R)-An-SDP catalytic system, highly enantioenriched cyclization addition products were obtained in good yields and with excellent enantioselectivities.

引用

页码：1291 / 1294

页数：4

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