Rhodium-Catalyzed Asymmetric Cyclization/Addition Reactions of 1,6-Enynes and Oxa/Azabenzonorbornadienes

被引：22
|
作者：
Zhou, Yongyun [1 ]
Yu, Lu [1 ]
Chen, Jingchao [1 ]
Xu, Jianbin [1 ]
He, Zhenxiu [1 ]
Shen, Guoli [1 ]
Fan, Baomin [1 ,2 ]
机构：
[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Yunnan, Peoples R China
[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 05期
基金：
中国国家自然科学基金;
关键词：
RING-OPENING REACTIONS; 2+2 CYCLOADDITION; BICYCLIC ALKENES; ENZYMATIC DESYMMETRISATION; TERMINAL ALKYNES; OXABENZONORBORNADIENES; AZABENZONORBORNADIENES; CYCLOISOMERIZATION; HYDROALKYNYLATION; (+)-HOMOCHELIDONINE;
D O I：
10.1021/acs.orglett.7b04044
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild, efficient, and novel rhodium catalyzed asymmetric cyclization addition domino reaction of oxa/azabenzonorbornadienes and 1,6-enynes is documented. Through the use of a [Rh(COD)(2)]BF4-(R)-An-SDP catalytic system, highly enantioenriched cyclization addition products were obtained in good yields and with excellent enantioselectivities.
引用
收藏
页码：1291 / 1294
页数：4
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