Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals

被引：48

作者：

Cao, Xiaodan ^{[1
]}

Cui, Yun ^{[1
]}

Zhang, Xiaoxia ^{[1
]}

Lou, Jiangtao ^{[1
]}

Zhou, Jun ^{[1
]}

Bei, Huafeng ^{[1
]}

Wei, Renxiong ^{[1
]}

机构：

[1] Ningbo Municipal Hosp Tradit Chinese Med, Dept Clin Lab, Ningbo 315000, Zhejiang, Peoples R China

来源：

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2018年 / 16卷

关键词：

Proteome; Spermatozoa; Sperm motility; Asthenozoospermia; Infertility; FLAGELLAR BEAT FREQUENCY; DENSE FIBER PROTEINS; HUMAN SPERM TAIL; SEMEN QUALITY; MAMMALIAN SPERMATOZOA; SURFACE-ANTIGENS; SEMINAL PLASMA; FIBROUS SHEATH; MALE-FERTILITY; MOTILITY;

D O I：

10.1186/s12958-018-0334-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance.

引用

页数：8

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