Targeting soluble guanylate cyclase for the treatment of pulmonary hypertension

被引:0
作者
Lasker, George F. [1 ]
Maley, Jason H. [1 ]
Pankey, Edward A. [1 ]
Kadowitz, Philip J. [1 ]
机构
[1] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA
关键词
activators; endothelial dysfunction; nitric oxide; pulmonary hypertension; soluble guanylate cyclase; stimulators; CONTINUOUS INTRAVENOUS EPOPROSTENOL; SYSTEMIC VASODILATOR RESPONSES; PLACEBO-CONTROLLED TRIAL; NITRIC-OXIDE RECEPTOR; ARTERIAL-HYPERTENSION; DOUBLE-BLIND; INDEPENDENT ACTIVATION; PROSTACYCLIN ANALOG; CELL-PROLIFERATION; BOSENTAN THERAPY;
D O I
10.1586/ERS.11.9
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Pulmonary arterial hypertension is a disease characterized by a sustained increase in pulmonary arterial pressure leading to right heart failure. Current treatments focus on endothelial dysfunction and an aberrant regulatory pathway for vascular tone. Unfortunately, a large proportion of patients are unresponsive to conventional vasodilator therapy. Investigations are ongoing into the effects of experimental therapies targeting the signal transduction pathway that mediates vasodilation. Here, we briefly discuss the pathophysiology of pulmonary hypertension and endothelial dysfunction, along with current treatments. We then present a focused review of recent animal studies and human trials examining the use of activators and stimulators of soluble guanylate cyclase for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
引用
收藏
页码:153 / 161
页数:9
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