Steroidal saponins from the roots of Smilax aspera subsp mauritanica

被引：25

作者：

Belhouchet, Zineddine ^{[1
]}

Sautour, Marc ^{[1
]}

Miyamoto, Tomofumi ^{[2
]}

Lacaille-Dubois, Marie-Aleth ^{[1
]}

机构：

[1] Univ Bourgogne, Fac Pharm, Lab Pharmacognosie, Unite UMIB UPRES EA 3660, F-21079 Dijon, France

[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 09期

关键词：

Smilax aspera subsp mauritanica; Liliaceae; steroidal saponin; resveratrol; 2D-NMR; antifungal activity;

D O I：

10.1248/cpb.56.1324

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new steroidal saponins (1, 2) were isolated from the roots of Smilax aspera subsp. mauritanica (POIR.) ARCANG. (Liliaceae), together with the known curillin G (3), asparagoside E (4), asparoside A (5), asparoside B (6) and the phenolic compound resveratrol (7). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 3 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C glabrata and C tropicalis (minimum inhibitory concentrations of 25, 25 and 50 mu g/ml, respectively) whereas the other compounds were inactive.

引用

页码：1324 / 1327

页数：4

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