Using lithium as a neuroprotective agent in patients with cancer

被引：32

作者：

Khasraw, Mustafa ^{[1
,2
,3
]}

Ashley, David ^{[1
,2
]}

Wheeler, Greg ^{[4
]}

Berk, Michael ^{[1
,2
,5
,6
,7
,8
]}

机构：

[1] Geelong Hosp, Andrew Love Canc Ctr, Geelong, Vic, Australia

[2] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia

[3] Royal Melbourne Hosp, Parkville, Vic 3050, Australia

[4] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[5] Mental Hlth Res Inst, Parkville, Vic, Australia

[6] Orygen Youth Hlth Res Ctr, Parkville, Vic, Australia

[7] Ctr Youth Mental Hlth, Parkville, Vic, Australia

[8] Univ Melbourne, Dept Psychiat, Melbourne, Vic 3010, Australia

来源：

BMC MEDICINE | 2012年 / 10卷

关键词：

GLUTAMATE-RECEPTOR SUPERSENSITIVITY; HIPPOCAMPAL NEUROGENESIS; BREAST-CANCER; RADIATION-THERAPY; STEM-CELL; COGNITIVE FUNCTION; SYNTHASE KINASE-3; BRAIN; IRRADIATION; SURVIVORS;

D O I：

10.1186/1741-7015-10-131

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurocognitive impairment is being increasingly recognized as an important issue in patients with cancer who develop cognitive difficulties either as part of direct or indirect involvement of the nervous system or as a consequence of either chemotherapy-related or radiotherapy-related complications. Brain radiotherapy in particular can lead to significant cognitive defects. Neurocognitive decline adversely affects quality of life, meaningful employment, and even simple daily activities. Neuroprotection may be a viable and realistic goal in preventing neurocognitive sequelae in these patients, especially in the setting of cranial irradiation. Lithium is an agent that has been in use for psychiatric disorders for decades, but recently there has been emerging evidence that it can have a neuroprotective effect. This review discusses neurocognitive impairment in patients with cancer and the potential for investigating the use of lithium as a neuroprotectant in such patients.

引用

页数：7

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