Transient efficacy of double high-dose chemotherapy and autologous peripheral stem cell transplantation, immunoglobulin, thalidomide, and bortezomib in the treatment of scleromyxedema

被引：21

作者：

Ataergin, Selmin ^{[1
,2
]}

Arpaci, Fikret ^{[1
,2
]}

Demiriz, Murat ^{[3
]}

Ozet, Ahmet ^{[1
,2
]}

机构：

[1] GATA Gulhane Fac Med, Dept Med Oncol, TR-06010 Ankara, Turkey

[2] GATA Gulhane Fac Med, Bone Marrow Transplantat Unit, TR-06010 Ankara, Turkey

[3] GATA Gulhane Fac Med, Dept Pathol, TR-06010 Ankara, Turkey

来源：

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY | 2008年 / 9卷 / 04期

关键词：

D O I：

10.2165/00128071-200809040-00008

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Scleromyxedema is a rare disorder characterized by mucin deposits in the dermis and monoclonal gammopathy. No definitive treatment of this condition has been described to date. We present the case of a 38-year-old male patient with scleromyxedema who underwent double consecutive autologous peripheral stem cell transplantations and received immunoglobulin, thalidomide, and bortezomib. This resulted in considerable clinical and pathologic amelioration of the patient's condition. However, 3 years after the second transplant, the patient relapsed and manifested the same skin lesions evident at his initial presentation.

引用

页码：271 / 273

页数：3

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