Filamentous influenza viruses

被引：72

作者：

Dadonaite, Bernadeta ^{[1
]}

Vijayakrishnan, Swetha ^{[2
]}

Fodor, Ervin ^{[1
]}

Bhella, David ^{[2
]}

Hutchinson, Edward C. ^{[1
,2
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, South Parks Rd, Oxford OX1 3RE, England

[2] Univ Glasgow, MRC, Ctr Virus Res, 464 Bearsden Rd, Glasgow G61 1QH, Lanark, Scotland

来源：

JOURNAL OF GENERAL VIROLOGY | 2016年 / 97卷

基金：

英国惠康基金;

关键词：

A VIRUS; MATRIX PROTEIN; ELECTRON-MICROSCOPY; M1; PROTEIN; M2; PARTICLE FORMATION; CYTOPLASMIC TAILS; VIRION MORPHOLOGY; RYAN STRAIN; IN-VIVO;

D O I：

10.1099/jgv.0.000535

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarize what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.

引用

页码：1755 / 1764

页数：10

共 97 条

[1] INFECTIVITY OF INFLUENZA VIRUS FILAMENTS [J].