Synthesis and antibacterial activity of 4",11-di-O-arylalkylcarbamoyl azithromycin derivatives

被引：21
|
作者：
Ma, Shutao [1 ]
Jiao, Bo [1 ]
Liu, Zhaopeng [1 ]
Wang, Hui [2 ]
Xian, Ruiqing [1 ]
Zheng, Manjie [1 ]
Lou, Hongxiang [1 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China
[2] Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 06期
基金：
中国国家自然科学基金;
关键词：
4; 11-Disubstituted azithromycin; Synthesis; Antibacterial activity; Macrolide resistance; KETOLIDES;
D O I：
10.1016/j.bmcl.2009.01.092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new 4 '',11-di-O-arylalkylcarbamoyl azithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. Some derivatives exhibited greatly improved activity against erythromycin-resistant bacteria. Among them, compounds 5f and 5k were found to have potent activity against erythromycin-resistant Streptococcus pneumoniae whose resistance was encoded by the erm or mef gene. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1698 / 1701
页数：4
相关论文
共 50 条
  • [41] Synthesis and Antibacterial Activity of Novel Chalcone Derivatives of Apocynin
    Janaki, P.
    Bhadraiah, B.
    Nagarjuna, P. Acharya
    Subhashini, N. J. P.
    LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10 (10) : 923 - 927
  • [42] Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives
    Z. Azarkamanzad
    F. Farzaneh
    M. Ghandi
    M. M. Feizabadi
    S. Jasemi
    Russian Journal of Organic Chemistry, 2022, 58 : 372 - 378
  • [43] Thiopyrimidine derivatives: synthesis and antibacterial activity
    Baluja, S.
    Kacchadia, N.
    Chanda, S.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2012, 46 (02) : 117 - 121
  • [44] Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives
    Azarkamanzad, Z.
    Farzaneh, F.
    Ghandi, M.
    Feizabadi, M. M.
    Jasemi, S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (03) : 372 - 378
  • [45] Synthesis Characterization and Antibacterial Activity of 4-Ethynyl Chalcone Derivatives
    Raju, Dachepally
    Sreeramulu, J.
    Malleswarareddy, P.
    Nagaraju, N.
    Ramamohan, G.
    INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2022, 12 (02): : L78 - L85
  • [46] Design, Synthesis, and Antibacterial Activity of Morpholine-4-sulfonamide Derivatives
    Zou, Huimin
    Tan, Yi
    Huang, Zhiyou
    Yang, Ping
    Ou, Wenxia
    Li, Xiaohong
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (11) : 2259 - 2265
  • [47] Thiopyrimidine derivatives: synthesis and antibacterial activity
    S. Baluja
    N. Kacchadia
    S. Chanda
    Pharmaceutical Chemistry Journal, 2012, 46 : 117 - 121
  • [48] Synthesis and antibacterial activity of egonol derivatives
    Ozturk, Safiye Emirdag
    Akgul, Yurdanur
    Anil, Huseyin
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (08) : 4431 - 4437
  • [49] Synthesis and antibacterial activity of trinems bearing nitrogen derivatives at C(4)
    Andreotti D.
    Biondi S.
    Donati D.
    Chemistry of Heterocyclic Compounds, 1998, 34 (11) : 1324 - 1330
  • [50] Synthesis and Antibacterial Activity of 4-Methylsalicylic Acid Derivatives and Salicylanilides
    Arora, Rosheen
    Sharma, Shivali
    Kalia, Anu
    Utreja, Divya
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (07) : 1217 - 1224
12345