Synthesis and antibacterial activity of 4",11-di-O-arylalkylcarbamoyl azithromycin derivatives

被引：21

作者：

Ma, Shutao ^{[1
]}

Jiao, Bo ^{[1
]}

Liu, Zhaopeng ^{[1
]}

Wang, Hui ^{[2
]}

Xian, Ruiqing ^{[1
]}

Zheng, Manjie ^{[1
]}

Lou, Hongxiang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China

[2] Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 06期

基金：

中国国家自然科学基金;

关键词：

4; 11-Disubstituted azithromycin; Synthesis; Antibacterial activity; Macrolide resistance; KETOLIDES;

D O I：

10.1016/j.bmcl.2009.01.092

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new 4 '',11-di-O-arylalkylcarbamoyl azithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. Some derivatives exhibited greatly improved activity against erythromycin-resistant bacteria. Among them, compounds 5f and 5k were found to have potent activity against erythromycin-resistant Streptococcus pneumoniae whose resistance was encoded by the erm or mef gene. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1698 / 1701

页数：4

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