Clinical significance of frontal cortex abnormalities in Huntington's disease

被引:12
作者
Wolf, Robert Christian [1 ]
Kloeppel, Stefan [2 ,3 ,4 ]
机构
[1] Heidelberg Univ, Dept Gen Psychiat, Ctr Psychosocial Med, D-69115 Heidelberg, Germany
[2] Univ Freiburg, Div Freiburg Brain Imaging, D-79106 Freiburg, Germany
[3] Univ Freiburg, Dept Psychiat & Psychotherapy, D-79106 Freiburg, Germany
[4] Univ Freiburg, Dept Neurol, Freiburg, Germany
关键词
Huntington's disease; fMRI; Psychiatric symptoms; Clinical relevance; CEREBRAL-BLOOD-FLOW; PREFRONTAL CORTEX; WORKING-MEMORY; EMBRYONIC LETHALITY; ALZHEIMERS-DISEASE; DEFAULT-MODE; APATHY; DYSFUNCTION; DEPRESSION; EXPRESSION;
D O I
10.1016/j.expneurol.2013.03.022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:39 / 44
页数:6
相关论文
共 75 条
[1]   Functional and Structural MRI Biomarkers to Detect Pre-Clinical Neurodegeneration [J].
Abdulkadir, Ahmed ;
Ronneberger, Olaf ;
Wolf, Robert Christian ;
Pfleiderer, Bettina ;
Saft, Carsten ;
Kloeppel, Stefan .
CURRENT ALZHEIMER RESEARCH, 2013, 10 (02) :125-134
[2]  
Alexopoulos G. S., 2012, J AFFECT DI IN PRESS
[3]  
Bhide PG, 1996, J NEUROSCI, V16, P5523
[4]   Diffusion Tensor Imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits [J].
Bohanna, India ;
Georgiou-Karistianis, Nellie ;
Sritharan, Anusha ;
Asadi, Hamed ;
Johnston, Leigh ;
Churchyard, Andrew ;
Egan, Gary .
BRAIN IMAGING AND BEHAVIOR, 2011, 5 (03) :171-180
[5]   Connectivity-based segmentation of the striatum in Huntington's disease: Vulnerability of motor pathways [J].
Bohanna, India ;
Georgiou-Karistianis, Nellie ;
Egan, Gary F. .
NEUROBIOLOGY OF DISEASE, 2011, 42 (03) :475-481
[6]   Longitudinal imaging pattern analysis (SPARE-CD index) detects early structural and functional changes before cognitive decline in healthy older adults [J].
Clark, Vanessa H. ;
Resnick, Susan M. ;
Doshi, Jimit ;
Beason-Held, Lori L. ;
Zhou, Yun ;
Ferrucci, Luigi ;
Wong, Dean F. ;
Kraut, Michael A. ;
Davatzikos, Christos .
NEUROBIOLOGY OF AGING, 2012, 33 (12) :2733-2745
[7]   Longitudinal progression of Alzheimers-like patterns of atrophy in normal older adults: the SPARE-AD index [J].
Davatzikos, Christos ;
Xu, Feng ;
An, Yang ;
Fan, Yong ;
Resnick, Susan M. .
BRAIN, 2009, 132 :2026-2035
[8]   The Subgenual Anterior Cingulate Cortex in Mood Disorders [J].
Drevets, Wayne C. ;
Savitz, Jonathan .
CNS SPECTRUMS, 2008, 13 (08) :663-681
[9]   INACTIVATION OF THE MOUSE HUNTINGTONS-DISEASE GENE HOMOLOG HDH [J].
DUYAO, MP ;
AUERBACH, AB ;
RYAN, A ;
PERSICHETTI, F ;
BARNES, GT ;
MCNEIL, SM ;
GE, P ;
VONSATTEL, JP ;
GUSELLA, JF ;
JOYNER, AL ;
MACDONALD, ME .
SCIENCE, 1995, 269 (5222) :407-410
[10]  
Ferrante RJ, 1997, J NEUROSCI, V17, P3052