The effect of mupirocin dressings on postoperative surgical site infections in elective colorectal surgery: A prospective, randomized controlled trial

被引：7

作者：

Ahmad, Humera F. ^{[1
]}

Kallies, Kara J. ^{[2
]}

Shapiro, Stephen B. ^{[3
]}

机构：

[1] Gunderson Med Fdn, Dept Med Educ, La Crosse, WI USA

[2] Gunderson Med Fdn, Dept Med Res, La Crosse, WI USA

[3] Gundersen Hlth Syst, Dept Gen Surg, 1900 South Ave,Mail Stop C05-001, La Crosse, WI 54601 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2019年 / 217卷 / 06期

关键词：

Surgical site infection; Mupirocin; Wound dressing; Randomized trial; OINTMENT APPLICATION; PREVENTION;

D O I：

10.1016/j.amjsurg.2018.11.033

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Surgical site infections (SSIs) are the most common nosocomial infection among surgical patients. We hypothesized that mupirocin ointment would decrease SSI rates compared to standard surgical dressings in patients undergoing colorectal surgery. Methods: A prospective randomized controlled trial was performed, including patients undergoing elective open and minimally invasive colorectal surgery. Patients were randomized 1:1 to receive standard gauze dressings or mupirocin ointment (2%) dressings. The primary outcome was incisional SSI at 30 days postoperative. Results: A total of 192 patients were enrolled; 150 underwent randomization: 75 to the mupirocin arm, and 75 to the standard gauze dressing arm. Three SSIs occurred; one (1%) in the mupirocin group, and two (3%) in the standard gauze group (P = 0.560). There was no significant difference between standard gauze dressings and mupirocin dressings. Conclusion: Mupirocin (2%) ointment failed to show a benefit compared to standard dressings for postoperative SSI. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：1083 / 1088

页数：6