Cycling, stressed-out and nervous: cellular functions of c-Abl

被引：256

作者：

Van Etten, RA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Ctr Blood Res, Dept Genet, Boston, MA 02115 USA

来源：

TRENDS IN CELL BIOLOGY | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0962-8924(99)01549-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

c-Abl, the product of the cellular homologue of the transforming gene of Abelson murine leukaemia virus, has been a protein in search of a purpose for over two decades. Because c-Abl is implicated in the pathogenesis of several human leukaemias, understanding the functions of Abl is an important goal. Recently, biochemical and genetic approaches have converged to shed new light on the mechanism of regulation of c-Abl kinase activity and the multiple roles of c-Abl in cellular physiology. This review summarizes our current understanding of the many facets of c-Abl biology, emphasizing recent studies on Drosophila and mammalian Abl.

引用

页码：179 / 186

页数：8

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