Synovial sarcoma specific translocation on associated with both epithelial and spindle cell components

被引：0
作者：
Birdsall, S
Osin, P
Lu, YJ
Fisher, C
Shipley, J
机构：
[1] Inst Canc Res, Haddow Labs, Sect Mol Carcinogenesis, Sutton SM2 5NG, Surrey, England
[2] Inst Canc Res, Sect Cell Biol & Expt Pathol, Sutton SM2 5NG, Surrey, England
[3] Royal Marsden NHS Trust, Dept Anat Pathol, London, England
来源：
INTERNATIONAL JOURNAL OF CANCER | 1999年 / 82卷 / 04期
关键词：
D O I：
10.1002/(SICI)1097-0215(19990812)82:4<605::AID-IJC22>3.3.CO;2-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The biphasic subtype of synovial sarcoma consists of both epithelial and spindle cell components. To address the relationship between the different cellular components found in synovial sarcoma, we deduced the presence of the synovial sarcoma-specific der(X)t(X;18)(p11.2;q11.2), and involvement of the SSX1 gene in both the epithelial/glandular and spindle cell components of 3 biphasic synovial sarcomas with wide ranging proportions of each of the 2 elements. This has been achieved using a 2-color fluorescence in situ hybridization (FISH) methodology that we had developed recently for analysis paraffin-embedded material. The presence of the rearrangement could be deduced in histologically defined regions and the results showed clearly that the rearrangement was present in both cellular components. This finding provides direct genetic evidence for biphasic synovial sarcomas being clonal and truly biphasic. (C) 1999 Wiley-Liss, Inc.
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页码：605 / 608
页数：4
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