Exploiting Surface-Plasmon-Enhanced Light Scattering for the Design of Ultrasensitive Biosensing Modality

被引：24
作者：
Yang, Chih-Tsung [1 ]
Wu, Lin [3 ]
Liu, Xiaohu [2 ]
Nhung Thi Tran [2 ]
Ba, Ping [3 ]
Liedberg, Bo [2 ]
Wang, Yi [2 ,4 ,5 ]
Thierry, Benjamin [1 ]
机构：
[1] Univ South Australia, Future Ind Inst, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia
[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Ctr Biomimet Sensor Sci, Singapore 639798, Singapore
[3] ASTAR, Inst High Performance Comp, Elect & Photon Dept, Singapore 138632, Singapore
[4] Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325001, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Inst Biomat & Engn, Wenzhou 325035, Zhejiang, Peoples R China
来源：
ANALYTICAL CHEMISTRY | 2016年 / 88卷 / 23期
基金：
英国医学研究理事会;
关键词：
GOLD NANOPARTICLES; FLUORESCENCE SPECTROSCOPY; RESONANCE; SENSITIVITY; SIGNAL; SIZE; DNA; MICROARRAYS; ABSORPTION; CANCER;
D O I：
10.1021/acs.analchem.6b03798
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Development of new detection methodologies and amplification schemes is indispensable for plasmonic biosensors to improve the sensitivity for the detection of trace amounts of analytes. Herein, an ultrasensitive scheme for signal enhancement based on the concept of surface-plasmon-resonance-enhanced light scattering (SP-LS) was validated experimentally and theoretically. The SP-LS of gold nanoparticles' (AuNPs) tags was employed in a sandwich assay for the detection of cardiac troponin I and provided up to 2 orders of magnitude improved sensitivity over conventional AuNPs-enhanced refractometric measurements and 3 orders of magnitude improvement over label-free SPR. Simulations were also performed to provide insights into the physical mechanisms.
引用
收藏
页码：11924 / 11930
页数：7
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