S100+ cells: A new neuro-immune cross-talkers in lymph organs

被引：14

作者：

Huang, Jinyu ^{[1
]}

Zhu, Chunfang ^{[1
]}

Zhang, Peipei ^{[1
]}

Zhu, Qian ^{[1
]}

Liu, YanMei ^{[1
]}

Zhu, Zhansheng ^{[1
]}

Wang, MinChen ^{[1
]}

Li, Wenjie ^{[1
]}

Yang, Gang ^{[1
]}

Dong, Nan ^{[1
]}

Liu, Juan ^{[1
]}

Chen, Lian ^{[1
]}

Zhang, Yanlin ^{[1
]}

Yang, Runlin ^{[2
]}

Deng, Lili ^{[2
]}

Fan, Jun ^{[2
]}

Wang, Xiaochun ^{[1
]}

Liu, Jun ^{[1
]}

Ma, Bin ^{[1
]}

Fu, Qiang ^{[2
]}

Wu, Kaiyun ^{[1
]}

机构：

[1] Soochow Univ, Coll Med, Dept Anat, Suzhou 215123, Jiangsu, Peoples R China

[2] Jiangsu Inst Nucl Med, Jiangsu Key Lab Mol Nucl Med, Minist Hlth, Key Lab Nucl Med, Wuxi, Jiangsu, Peoples R China

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

关键词：

NERVOUS-SYSTEM; BRAIN; INNERVATION; PROTEINS;

D O I：

10.1038/srep01114

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Up to now, the 'hardwired' neural pathway of the neuro-immune regulation is not fully understood. Here we reported a new neural pathway which links sympathetic nerves with immune cells of the lymphoid tissues. Our results demonstrated that nerve fibers derived from superior cervical ganglion directly targeted only S100(+) cells in the cervical lymph nodes. Moreover, we found co-expression of neurotransmitters such as norepinephrine, vasoactive intestinal polypeptide and neuropeptide Y in the postganglionic sympathetic nerve endings that innervate S100(+) cells. Our findings suggested that S100(+) cells serve as a neuro-immune cross-talker in lymph organs that may play a significant role in transmitting signals of nervous cells to targeted immune cells. The new findings provide better understanding of the cross-talk mechanism between the nervous system and the immune system.

引用

页数：8

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