The 'pyrono route' to 4-hydroxy-2-quinolones and 4-hydroxy-2-pyridones

被引：42
作者：
Kappe, T [1 ]
机构：
[1] Karl Franzens Univ Graz, Inst Organ Chem, Organ Synth Grp, A-8010 Graz, Austria
来源：
FARMACO | 1999年 / 54卷 / 05期
关键词：
4-hydroxy-2-quinolones; 4-hydroxy-2-pyridones; 3-acyl-4-hydroxy-2-quinolones; 3-acyl-4-hydroxy-2-pyridones; dichloroacetyl-4-hydroxy-2-quinolones; dichloroacetyl-4-hydroxy-2-pyridones; 3-tetrazolylcarbonyl-4-hydroxy-quinolones;
D O I：
10.1016/S0014-827X(99)00030-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The condensation of N-substituted anilines 6, azomethines or enamines 13 with two equivalents of diethyl malonate yields pyrono-quinolones 8, 10-12 or pyrono-pyridones (for instance 15, 20, 23, 30, 34) in high yields and on large scale preparations. These pyrono-quinolones and -pyridones are therefore excellent intermediates in the synthesis of a vast number of compounds, a number of which have potential biological activity. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：309 / 315
页数：7
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