The 'pyrono route' to 4-hydroxy-2-quinolones and 4-hydroxy-2-pyridones

被引：42

作者：

Kappe, T ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Inst Organ Chem, Organ Synth Grp, A-8010 Graz, Austria

来源：

FARMACO | 1999年 / 54卷 / 05期

关键词：

4-hydroxy-2-quinolones; 4-hydroxy-2-pyridones; 3-acyl-4-hydroxy-2-quinolones; 3-acyl-4-hydroxy-2-pyridones; dichloroacetyl-4-hydroxy-2-quinolones; dichloroacetyl-4-hydroxy-2-pyridones; 3-tetrazolylcarbonyl-4-hydroxy-quinolones;

D O I：

10.1016/S0014-827X(99)00030-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The condensation of N-substituted anilines 6, azomethines or enamines 13 with two equivalents of diethyl malonate yields pyrono-quinolones 8, 10-12 or pyrono-pyridones (for instance 15, 20, 23, 30, 34) in high yields and on large scale preparations. These pyrono-quinolones and -pyridones are therefore excellent intermediates in the synthesis of a vast number of compounds, a number of which have potential biological activity. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：309 / 315

页数：7

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