International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

被引：3425

作者：

Wingerchuk, Dean M. ^{[1
]}

Banwell, Brenda ^{[3
]}

Bennett, Jeffrey L. ^{[4
,5
]}

Cabre, Philippe ^{[6
]}

Carroll, William ^{[7
]}

Chitnis, Tanuja ^{[8
]}

de Seze, Jerome ^{[9
]}

Fujihara, Kazuo ^{[10
]}

Greenberg, Benjamin ^{[11
,12
]}

Jacob, Anu ^{[13
]}

Jarius, Sven ^{[14
]}

Lana-Peixoto, Marco ^{[15
]}

Levy, Michael ^{[16
]}

Simon, Jack H. ^{[17
,18
]}

Tenembaum, Silvia ^{[19
]}

Traboulsee, Anthony L. ^{[20
]}

Waters, Patrick ^{[21
]}

Wellik, Kay E. ^{[2
]}

Weinshenker, Brian G. ^{[22
]}

机构：

[1] Mayo Clin, Dept Neurol, Scottsdale, AZ 85259 USA

[2] Mayo Clin, Dept Lib Serv, Scottsdale, AZ USA

[3] Childrens Hosp Philadelphia, Philadelphia, PA USA

[4] Univ Colorado Denver, Dept Neurol, Aurora, CO USA

[5] Univ Colorado Denver, Dept Ophthalmol, Aurora, CO USA

[6] Ctr Hosp Univ Ft de France, Serv Neurol, Fort De France, Martinique, France

[7] Sir Charles Gairdner Hosp, Dept Neurol, Perth, WA, Australia

[8] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[9] Strasbourg Univ, Dept Neurol, Strasbourg, France

[10] Tohoku Univ, Grad Sch Med, Dept Multiple Sclerosis Therapeut, Sendai, Miyagi 980, Japan

[11] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA

[12] Univ Texas SW Med Ctr Dallas, Dept Neurotherapeut, Dallas, TX 75390 USA

[13] Walton Ctr NHS Trust, Liverpool, Merseyside, England

[14] Univ Heidelberg Hosp, Dept Neurol, Mol Neuroimmunol Grp, Heidelberg, Germany

[15] Univ Fed Minas Gerais, Sch Med, Ctr Multiple Sclerosis Invest, Belo Horizonte, MG, Brazil

[16] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

[17] Portland VA Med Ctr, Portland, VA USA

[18] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[19] Natl Pediat Hosp Dr Juan P Garrahan, Dept Neurol, Buenos Aires, DF, Argentina

[20] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[21] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX1 2JD, England

[22] Mayo Clin, Dept Neurol, Rochester, MN USA

来源：

NEUROLOGY | 2015年 / 85卷 / 02期

关键词：

OLIGODENDROCYTE GLYCOPROTEIN ANTIBODIES; PARTIAL TRANSVERSE MYELITIS; TERM-FOLLOW-UP; MULTIPLE-SCLEROSIS; BRAIN ABNORMALITIES; NMO-IGG; AQUAPORIN-4; AUTOIMMUNITY; CLINICAL-COURSE; LESIONS; MULTICENTER;

D O I：

10.1212/WNL.0000000000001729

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria, with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD and opticospinal MS.

引用

页码：177 / 189

页数：13

共 60 条

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