The role of dendritic cells in innate and adaptive immunity to respiratory syncytial virus, and implications for vaccine development

被引：1
作者：
Garg, Ravendra [1 ]
Shrivastava, Pratima [1 ]
Littel-van den Hurk, Sylvia van Drunen [1 ,2 ]
机构：
[1] Univ Saskatchewan, VIDO Intervac, Saskatoon, SK S7N 5E3, Canada
[2] Univ Saskatchewan, Saskatoon, SK S7N 5E3, Canada
来源：
EXPERT REVIEW OF VACCINES | 2012年 / 11卷 / 12期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
dendritic cell subsets and maturation; innate and adaptive immunity; respiratory syncytial virus; vaccine; REGULATORY T-CELLS; FUSION F PROTEIN; MONOPHOSPHORYL-LIPID-A; ADULT-PERIPHERAL-BLOOD; TOLL-LIKE RECEPTORS; CPG OLIGODEOXYNUCLEOTIDES; RSV INFECTION; PULMONARY IMMUNOPATHOLOGY; ANTIBODY-RESPONSE; VIRAL-INFECTION;
D O I：
10.1586/ERV.12.117
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Expert Rev. Vaccines 11(12), 1441-1457 (2012) Respiratory syncytial virus (RSV) is a common human pathogen that causes cold-like symptoms in most healthy adults and children. However, RSV often moves into the lower respiratory tract in infants and young children predisposed to respiratory illness, making it the most common cause of pediatric broncheolitis and pneumonia. The development of an appropriate balanced immune response is critical for recovery from RSV, while an unbalanced and/or excessively vigorous response may lead to immunopathogenesis. Different dendritic cell (DC) subsets influence the magnitude and quality of the host response to RSV infection, with myeloid DCs mediating and plasmacytoid DCs modulating immunopathology. Furthermore, stimulation of DCs through Toll-like receptors is essential for induction of protective immunity to RSV. These characteristics have implications for the rational design of a RSV vaccine.
引用
收藏
页码：1441 / 1457
页数：17
相关论文
共 165 条
[1]   Nanoparticle vaccines against respiratory viruses [J].
Adair, Brian M. .
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2009, 1 (04) :405-414
[2]   Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes [J].
Angel Rico, Miguel ;
Trento, Alfonsina ;
Ramos, Manuel ;
Johnstone, Carolina ;
Del Val, Margarita ;
Antonio Melero, Jose ;
Lopez, Daniel .
IMMUNOLOGY AND CELL BIOLOGY, 2009, 87 (04) :344-350
[3]  
[Anonymous], 2010, BAYLOR RESEARCH INSTITUTE, Patent No. [US0061965, 0061965]
[4]   Dendritic cells and the control of immunity [J].
Banchereau, J ;
Steinman, RM .
NATURE, 1998, 392 (6673) :245-252
[5]   Respiratory syncytial virus decreases the capacity of myeloid dendritic cells to induce interferon-γ in naive T cells [J].
Bartz, H ;
Türkel, Ö ;
Hoffjan, S ;
Rothoeft, T ;
Gonschorek, A ;
Schauer, U .
IMMUNOLOGY, 2003, 109 (01) :49-57
[6]   Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus [J].
Belz, GT ;
Smith, CM ;
Kleinert, L ;
Reading, P ;
Brooks, A ;
Shortman, K ;
Carbone, FR ;
Heath, WR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (23) :8670-8675
[7]   DNA encoding the attachment (G) or fusion (F) protein of respiratory syncytial virus induces protection in the absence of pulmonary inflammation [J].
Bembridge, GP ;
Rodriguez, N ;
Garcia-Beato, R ;
Nicolson, C ;
Melero, JA ;
Taylor, G .
JOURNAL OF GENERAL VIROLOGY, 2000, 81 :2519-2523
[8]   Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection [J].
Beyer, M ;
Bartz, H ;
Hörner, K ;
Doths, S ;
Koerner-Rettberg, C ;
Schwarze, J .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (01) :127-133
[9]   ChemR23 Dampens Lung Inflammation and Enhances Anti-viral Immunity in a Mouse Model of Acute Viral Pneumonia [J].
Bondue, Benjamin ;
Vosters, Olivier ;
de Nadai, Patricia ;
Glineur, Stephanie ;
De Henau, Olivier ;
Luangsay, Souphalone ;
Van Gool, Frederic ;
Communi, David ;
De Vuyst, Paul ;
Desmecht, Daniel ;
Parmentier, Marc .
PLOS PATHOGENS, 2011, 7 (11)
[10]   Respiratory syncytial virus differentially activates murine myeloid and plasmacytoid dendritic cells [J].
Boogaard, Ivette ;
van Oosten, Marijke ;
van Rijt, Leonie S. ;
Muskens, Femke ;
Kimman, Tjeerd G. ;
Lambrecht, Bart N. ;
Buisman, Anne-Marie .
IMMUNOLOGY, 2007, 122 (01) :65-72
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