From Systems Biology to Systems Biomedicine

被引：21

作者：

Antony, Paul M. A. ^{[1
]}

Balling, Rudi ^{[1
]}

Vlassis, Nikos ^{[1
]}

机构：

[1] Univ Luxembourg, Luxembourg Ctr Syst Biomed, Luxembourg, Luxembourg

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2012年 / 23卷 / 04期

关键词：

CIRCUITS; DYNAMICS; GENOME; GENES; BLOOD;

D O I：

10.1016/j.copbio.2011.11.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Systems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well. The challenge in Systems Biomedicine is to furthermore translate mechanistic insights in biological systems to clinical application, with the central aim of improving patients' quality of life. The challenge is to find theoretically well-chosen models for the contextually correct and intelligible representation of multi-scale biological systems. In this review, we discuss the current state of Systems Biology, highlight the emergence of Systems Biomedicine, and highlight some of the topics and views that we think are important for the efficient application of Systems Theory in Biomedicine.

引用

页码：604 / 608

页数：5

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