SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES

被引：0

作者：

Tang, Youzhi ^{[1
]}

Luo, Jian ^{[1
]}

Chen, Xiaojie ^{[1
]}

Wang, Bo ^{[1
]}

Shen, Xiangguang ^{[1
]}

Liu, Jianhua ^{[1
]}

机构：

[1] South China Agr Univ, Coll Vet Med, Guangdong Prov Key Lab Vet Pharmaceut Dev & Safet, Guangzhou 510642, Guangdong, Peoples R China

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2013年 / 58卷 / 01期

基金：

中国国家自然科学基金;

关键词：

pleuromutilin derivatives; antibacterial; Staphylococcus aureus; PART; 1; ANTIBIOTICS; BINDING; FIT;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four novel pleuromutilin derivatives with butyl amine group in the C-14 side-chain were designed, synthesized and confirmed by FT-IR, H-1-NMR and HR-MS. The results of antibacterial activity showed that the antibacterial activity of pleuromutilin derivatives could be affected by the steric hindrance of their C-14 side-chain.

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页码：1537 / 1540

页数：4

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