Endurance Exercise Intervention Is Beneficial to Kidney Function in a Rat Model of Isolated Abdominal Venous Congestion: a Pilot Study

被引：3

作者：

Cops, Jirka ^{[1
,2
]}

De Moor, Bart ^{[1
,3
]}

Haesen, Sibren ^{[1
,2
]}

Lijnen, Lien ^{[1
]}

Wens, Inez ^{[4
]}

Lemoine, Lieselotte ^{[1
,5
]}

Reynders, Carmen ^{[6
]}

Penders, Joris ^{[1
,6
]}

Lambrichts, Ivo ^{[1
]}

Mullens, Wilfried ^{[1
,7
]}

Hansen, Dominique ^{[1
,8
,9
]}

机构：

[1] UHasselt Univ Hasselt, BIOMED, Agoralaan, B-3590 Diepenbeek, Belgium

[2] UHasselt Univ Hasselt, Fac Med & Life Sci, Agoralaan, B-3590 Diepenbeek, Belgium

[3] Jessa Ziekenhuis, Dept Nephrol, B-3500 Hasselt, Belgium

[4] Univ Antwerp, Fac Med & Hlth Sci, Vaccine & Infect Dis Inst, Lab Expt Hematol, B-2000 Antwerp, Belgium

[5] Ziekenhuis Oost Limburg, Dept Surg Oncol, B-3600 Genk, Belgium

[6] Ziekenhuis Oost Limburg, Clin Lab, B-3600 Genk, Belgium

[7] Ziekenhuis Oost Limburg, Dept Cardiol, B-3600 Genk, Belgium

[8] UHasselt Univ Hasselt, REVAL, Agoralaan, B-3590 Diepenbeek, Belgium

[9] Jessa Ziekenhuis, Heart Ctr, B-3500 Hasselt, Belgium

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2020年 / 13卷 / 05期

关键词：

Abdominal venous congestion; Moderate intense endurance exercise training; Cardiac function; renal function; rat model; INFERIOR VENA-CAVA; HEART-FAILURE; INJURY MOLECULE-1; RENAL-FUNCTION; DYSFUNCTION; INTENSITY; RATIONALE; BIOMARKER; PRESSURE;

D O I：

10.1007/s12265-019-09947-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, the effects of moderate intense endurance exercise on heart and kidney function and morphology were studied in a thoracic inferior vena cava constricted (IVCc) rat model of abdominal venous congestion. After IVC surgical constriction, eight sedentary male Sprague-Dawley IVCc rats (IVCc-SED) were compared to eight IVCc rats subjected to moderate intense endurance exercise (IVCc-MOD). Heart and kidney function was examined and renal functional reserve (RFR) was investigated by administering a high protein diet (HPD). After 12 weeks of exercise training, abdominal venous pressure, indices of body fat content, plasma cystatin C levels, and post-HPD urinary KIM-1 levels were all significantly lower in IVCc-MOD versus IVCc-SED rats (P < 0.05). RFR did not differ between both groups. The implementation of moderate intense endurance exercise in the IVCc model reduces abdominal venous pressure and is beneficial to kidney function.

引用

页码：769 / 782

页数：14

共 42 条

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