Urothelial carcinoma with squamous differentiation-The pathologists' perspective

被引:21
作者
Gellert, Lan L. [1 ]
Warrick, Joshua [2 ]
Al-Ahmadie, Hikmat A. [3 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA
[2] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
关键词
Urothelial carcinoma; Squamous differentiation; Squamous cell carcinoma; Variant histology; Molecular subtypes; DIVERGENT HISTOLOGIC DIFFERENTIATION; MOLECULAR-WEIGHT CYTOKERATIN; CELL-CARCINOMA; BLADDER-CANCER; PROSTATE ADENOCARCINOMA; HUMAN-PAPILLOMAVIRUS; IMMUNOHISTOCHEMICAL EVALUATION; RADICAL CYSTECTOMY; POTENTIAL UTILITY; UROPLAKIN-III;
D O I
10.1016/j.urolonc.2015.07.018
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Squamous differentiation is the most common variant histology in urothelial carcinoma and may have effects on clinical outcome. Inconsistencies in reporting variant histologies in urothelial carcinoma are well documented. Immunohistochemical and molecular markers may help identify tumors with squamous differentiation beyond light microscopy. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:437 / 443
页数:7
相关论文
共 54 条
  • [1] p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma
    Alexander, Riley E.
    Hu, Yingchuan
    Kum, Jennifer B.
    Montironi, Rodolfo
    Lopez-Beltran, Antonio
    MacLennan, Gregory T.
    Idrees, Muhammad T.
    Emerson, Robert E.
    Ulbright, Thomas M.
    Grignon, David G.
    Eble, John N.
    Cheng, Liang
    [J]. MODERN PATHOLOGY, 2012, 25 (11) : 1526 - 1533
  • [2] Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications
    Amin, Mahul B.
    [J]. MODERN PATHOLOGY, 2009, 22 : S96 - S118
  • [3] [Anonymous], WHO CLASSIFICATION T
  • [4] Antunes Alberto A., 2007, Int. braz j urol., V33, P339, DOI 10.1590/S1677-55382007000300006
  • [5] Coordinate expression of cytokeratins 7 and 20 in prostate adenocarcinoma and bladder urothelial carcinoma
    Bassily, NH
    Vallorosi, CJ
    Akdas, G
    Montie, JE
    Rubin, MA
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2000, 113 (03) : 383 - 388
  • [6] CLINICOPATHOLOGIC STUDY OF SQUAMOUS-CELL CARCINOMA OF BLADDER
    BESSETTE, PL
    ABELL, MR
    HERWIG, KR
    [J]. JOURNAL OF UROLOGY, 1974, 112 (01) : 66 - 67
  • [7] Squamous and/or glandular differentiation in urothelial carcinoma: Prevalence and significance in transurethral resections of the bladder
    Billis A.
    Schenka A.A.
    Ramos C.C.O.
    Carneiro L.T.
    Araújo V.
    [J]. International Urology and Nephrology, 2001, 33 (4) : 631 - 633
  • [8] Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection
    Blochin, Elen B.
    Park, Kay J.
    Tickoo, Satish K.
    Reuter, Victor E.
    Al-Ahmadie, Hikmat
    [J]. MODERN PATHOLOGY, 2012, 25 (11) : 1534 - 1542
  • [9] Inverse p16 and p63 Expression in Small Cell Carcinoma and High-Grade Urothelial Cell Carcinoma of the Urinary Bladder
    Buza, Natalia
    Cohen, Paul J.
    Hui, Pei
    Parkash, Vinita
    [J]. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2010, 18 (02) : 94 - 102
  • [10] Chalasani Venu, 2009, Can Urol Assoc J, V3, pS193