Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species

被引：28

作者：

Youssef, Diaa T. A. ^{[1
]}

Alahdal, Abdulrahman M. ^{[2
]}

机构：

[1] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, Jeddah 21589, Saudi Arabia

来源：

MOLECULES | 2018年 / 23卷 / 02期

关键词：

marine Penicillium sp; 2,5-diketopiperazines; cytotoxic and antimicrobial activities; NATURAL-PRODUCTS; DIKETOPIPERAZINES; 2,5-DIKETOPIPERAZINES; ORGANISMS; ALKALOIDS; TUNICATE; SPONGE;

D O I：

10.3390/molecules23020394

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro-S-Phe) (3) and cyclo(R-Pro-R-Phe) (4). The structures of compounds 1-4 were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds 2-4 displayed variable cytotoxic and antimicrobial activities.

引用

页数：8

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