Clinical potentials of neuropeptide Y family of hormones

被引：72

作者：

Balasubramaniam, A ^{[1
]}

机构：

[1] Univ Cincinnati, Med Ctr, Dept Surg, Div Gastrointestinal Hormones, Cincinnati, OH 45267 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2002年 / 183卷 / 04期

关键词：

clinical utility; disease; ligands; NPY; PP; PYY; receptors;

D O I：

10.1016/S0002-9610(02)00803-6

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Neuropeptide Y (NPY) family of hormones exhibits a wide spectrum of central and peripheral activities mediated by six G-protein coupled receptor subtypes denoted as Y-1, Y-2, Y-3, Y-4, Y-5, and y6. Investigations to date have implicated NPY in the pathophysiology of a number of diseases including feeding disorders, seizures, anxiety, diabetes, hypertension, congestive heart failure and intestinal disorders. These observations suggest that long-acting, potent NPY receptor selective agonists and antagonists developed could be used to treat a variety of diseases. These possibilities are discussed in this paper. (C) 2002 Excerpta Medics, Inc. All rights reserved.

引用

收藏

页码：430 / 434

页数：5

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