The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats

被引：39
|
作者：
Xu, Jing-Shu [1 ]
Li, Yao [1 ]
Cao, Xue [1 ]
Cui, Yun [1 ]
机构：
[1] First Peoples Hosp Yunnan, Kunhua Hosp, Dept Oral Med, Kunming 650032, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2013年 / 5卷 / 06期
关键词：
dental caries; Streptococcus mutans; acid production; adherence; glucosyltransferase; eugenol; IN-VITRO; VIRULENCE; BACTERIA; GLUCAN;
D O I：
10.3892/etm.2013.1066
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Eugenol has been widely used in medicine due to its antibacterial, anti-inflammatory, antioxidant, anticancer and analgesic properties. The present study was designed to investigate the effects of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats. Eugenol demonstrated significant inhibitory effects against acid production by S. mutans. The synthesis of water-insoluble glucans by glucosyltransferases was reduced by eugenol. Eugenol also markedly suppressed the adherence of S. mutans to saliva-coated hydroxyapatite beads. Furthermore, topical application of eugenol reduced the incidence and severity of carious lesions in rats. These results suggest that the natural compound eugenol may be a useful therapeutic agent for dental caries.
引用
收藏
页码：1667 / 1670
页数：4
相关论文
共 50 条
  • [11] EFFECT OF CHEESE, WITH AND WITHOUT SUCROSE, ON DENTAL-CARIES AND RECOVERY OF STREPTOCOCCUS-MUTANS IN RATS
    ROSEN, S
    MIN, DB
    HARPER, DS
    HARPER, WJ
    BECK, EX
    BECK, FM
    JOURNAL OF DENTAL RESEARCH, 1984, 63 (06) : 894 - 896
  • [12] INTERRELATIONSHIP BETWEEN STREPTOCOCCUS-SANGUIS AND STREPTOCOCCUS-MUTANS IN DENTAL-CARIES DEVELOPMENT IN GNOTOBIOTIC-RATS
    KUPP, L
    ROSEN, S
    BECK, FM
    FIVESTAYLOR, P
    CARIES RESEARCH, 1988, 22 (02) : 113 - 113
  • [13] Effect of nicotine on cariogenic virulence of Streptococcus mutans
    Li, Mingyun
    Huang, Ruijie
    Zhou, Xuedong
    Qiu, Wei
    Xu, Xin
    Gregory, Richard L.
    FOLIA MICROBIOLOGICA, 2016, 61 (06) : 505 - 512
  • [14] Effect of nicotine on cariogenic virulence of Streptococcus mutans
    Mingyun Li
    Ruijie Huang
    Xuedong Zhou
    Wei Qiu
    Xin Xu
    Richard L. Gregory
    Folia Microbiologica, 2016, 61 : 505 - 512
  • [15] Inhibiting effect of Dorstenia asaroides extracts on cariogenic properties of Streptococcus mutans
    D'Angelis, C. E. M.
    Leite, M. F.
    Sousa, J. P. B.
    Alonso, L.
    Polizello, A. C. M.
    Groppo, M., Jr.
    Aires, C. P.
    Bastos, J. K.
    Spadaro, A. C. C.
    ANAEROBE, 2012, 18 (01) : 31 - 36
  • [16] Therapeutic effect of llama derived VHH fragments against Streptococcus mutans on the development of dental caries
    Carina Krüger
    Anna Hultberg
    Harold Marcotte
    Pim Hermans
    Sandra Bezemer
    Leon G. J. Frenken
    Lennart Hammarström
    Applied Microbiology and Biotechnology, 2006, 72 : 732 - 737
  • [17] Therapeutic effect of llama derived VHH fragments against Streptococcus mutans on the development of dental caries
    Kruger, Carina
    Hultberg, Anna
    Marcotte, Harold
    Hermans, Pim
    Bezemer, Sandra
    Frenken, Leon G. J.
    Hammarstrom, Lennart
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2006, 72 (04) : 732 - 737
  • [18] Antibacterial effect of Juglans Regia against dental caries Streptococcus mutans
    Abdullah, Zhian G.
    Swilaiman, Sameira S.
    Ahmad, Suha H.
    Darogha, Suhaila N.
    PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, 2020, 14 (02): : 1313 - 1317
  • [19] EFFECT ON DENTAL-CARIES OF ADAPTATION OF STREPTOCOCCUS-MUTANS TO FLUORIDE
    VANLOVEREN, C
    TENCATE, JM
    CARIES RESEARCH, 1988, 22 (02) : 117 - 117
  • [20] CARIES POTENTIAL OF STREPTOCOCCUS SANGUIS AND STREPTOCOCCUS MUTANS IN RATS
    HUXLEY, HG
    JOURNAL OF DENTAL RESEARCH, 1973, 52 (03) : 584 - 584
12345