Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE)

被引：67

作者：

Janko, C. ^{[1
]}

Schorn, C. ^{[1
]}

Grossmayer, G. E. ^{[1
]}

Frey, B. ^{[2
]}

Herrmann, M. ^{[1
]}

Gaipl, U. S. ^{[2
]}

Munoz, L. E. ^{[1
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nuremberg, Inst Clin Immunol & Rheumatol, Dept Internal Med 3, D-91054 Erlangen, Germany

[2] Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Radiat Oncol, D-91054 Erlangen, Germany

来源：

AUTOIMMUNITY REVIEWS | 2008年 / 8卷 / 01期

关键词：

Clearance; SLE; Nuclear fragments; Inflammation; Autoimmunity;

D O I：

10.1016/j.autrev.2008.07.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Deficiencies in the recognition and phagocytosis of dead and dying cells have been shown to be one of the main alterations in patients with systemic lupus erythematosus (SLE). Cellular as well as humoral elements play an important role in the clearance of apoptotic and necrotic cells. Non-ingested nuclear material may provide survival signals for autoreactive B-cells and consequently antibodies directed against nuclear structures will be produced. In healthy individuals, nuclear fragments are not phagocytosed in whole blood. Instead, they are mainly degraded by the action of plasma DNases and complement factors. In contrast, the uptake of nuclear fragments by blood-borne phagocytes is increased in most patients with SLE. The phagocytosis of this kind of prey, which might be opsonised by autoantibodies, may contribute to the maintenance of inflammatory responses in SLE. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：9 / 12

页数：4

共 22 条

[1] LIGATED COMPLEMENT RECEPTORS DO NOT ACTIVATE THE ARACHIDONIC-ACID CASCADE IN RESIDENT PERITONEAL-MACROPHAGES [J].