Plasma total homocysteine and subarachnoid haemorrhage in a co-factor replete population

被引：8

作者：

McEvoy, AW

Marras, C

Kitchen, ND

Briddon, A

机构：

[1] UCL Natl Hosp Neurol & Neurosurg, Dept Surg Neurol, London WC1N 3BG, England

[2] UCL Natl Hosp Neurol & Neurosurg, Dept Clin Biochem, London WC1N 3BG, England

[3] Univ Milan, Maggiore Policlin Hosp, Inst Neurosurg, IRCCS, Milan, Italy

来源：

AMINO ACIDS | 2001年 / 21卷 / 03期

关键词：

amino acids; homocysteine; subarachnoid haemorrhage; stroke; folate; vitamin B12;

D O I：

10.1007/s007260170009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mild hyperhomocysteinaemia is a postulated risk factor for occlusive vascular disease, including stroke. Subarachnoid haemorrhage (SAH) has an annual incidence of 10-20 per 100,000 and accounts for 5-10% of all strokes. Measurement of plasma total homocysteine (tHcy) in a cohort of vitamin B12 and folate replete patients did not reveal any association between tHcy and the aetiology of SAH.

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页码：237 / 241

页数：5

相关论文

共 12 条

[1] A PROSPECTIVE-STUDY OF ACUTE CEREBROVASCULAR-DISEASE IN THE COMMUNITY - THE OXFORDSHIRE COMMUNITY STROKE PROJECT 1981-86 .2. INCIDENCE, CASE FATALITY RATES AND OVERALL OUTCOME AT ONE YEAR OF CEREBRAL INFARCTION, PRIMARY INTRACEREBRAL AND SUBARACHNOID HEMORRHAGE [J].

BAMFORD, J ;

SANDERCOCK, P ;

DENNIS, M ;

BURN, J ;

WARLOW, C .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (01) :16-22

[2]

BRATTSTROM L, 1992, NEUROL RES, V14, P81, DOI 10.1080/01616412.1992.11740017

[3] Total plasma homocysteine as part of the routine aminogram by ion-exchange chromatography [J].

Briddon, A .

AMINO ACIDS, 1998, 15 (03) :235-239

[4] Vegan diet-based lifestyle program rapidly lowers homocysteine levels [J].

DeRose, DJ ;

Charles-Marcel, ZL ;

Jamison, JM ;

Muscat, JE ;

Braman, MA ;

McLane, GD ;

Mullen, JK .

PREVENTIVE MEDICINE, 2000, 30 (03) :225-233

[5]

Donnelly JG, 2000, ANN CLIN BIOCHEM, V37, P304

[6] TOTAL PLASMA HOMOCYSTEINE - INFLUENCE OF SOME COMMON PHYSIOLOGICAL VARIABLES [J].

FERMO, I ;

DEVECCHI, E ;

DANGELO, SV ;

DANGELO, A ;

PARONI, R .

AMINO ACIDS, 1993, 5 (01) :17-21

[7] Plasma homocysteine as a risk factor for vascular disease - The European concerted action project [J].

Graham, IM ;

Daly, LE ;

Refsum, HM ;

Robinson, K ;

Brattstrom, LE ;

Ueland, PM ;

PalmaReis, RJ ;

Boers, GHJ ;

Sheahan, RG ;

Israelsson, B ;

Uiterwaal, CS ;

Meleady, R ;

McMaster, D ;

Verhoef, P ;

Witteman, J ;

Rubba, P ;

Bellet, H ;

Wautrecht, JC ;

deValk, HW ;

Luis, ACS ;

ParrotRoulaud, FM ;

Tan, KS ;

Higgins, I ;

Garcon, D ;

Medrano, MJ ;

Candito, M ;

Evans, AE ;

Andria, G .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (22) :1775-1781

[8] Homocysteine and hemostasis: Pathogenetic mechanisms predisposing to thrombosis [J].

Harpel, PC ;

Zhang, XX ;

Borth, W .

JOURNAL OF NUTRITION, 1996, 126 (04) :S1285-S1289

[9] Incidence of subarachnoid hemorrhage - Role of region, year, and rate of computed tomography: A meta-analysis [J].

Linn, FHH ;

Rinkel, GJE ;

Algra, A ;

vanGijn, J .

STROKE, 1996, 27 (04) :625-629

[10] HOMOCYSTEINE THEORY OF ARTERIOSCLEROSIS [J].

MCCULLY, KS ;

WILSON, RB .

ATHEROSCLEROSIS, 1975, 22 (02) :215-227