Reconciliation of classification systems defining molecular subtypes of colorectal cancer

被引：63

作者：

Sadanandam, Anguraj ^{[1
,2
]}

Wang, Xin ^{[3
]}

de Sousa E Melo, Felipe ^{[4
]}

Gray, Joe W. ^{[5
]}

Vermeulen, Louis ^{[3
,4
]}

Hanahan, Douglas ^{[2
]}

Medema, Jan Paul ^{[4
]}

机构：

[1] Swiss Inst Bioinformat, Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol Lausanne, Swiss Inst Expt Canc Res, CH-1015 Lausanne, Switzerland

[3] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England

[4] Univ Amsterdam, Acad Med Ctr, Ctr Expt Mol Med, Lab Expt Oncol & Radiobiol, NL-1105 AZ Amsterdam, Netherlands

[5] Oregon Hlth & Sci Univ, Dept Biomed Engn, Portland, OR 97201 USA

来源：

CELL CYCLE | 2014年 / 13卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

colorectal cancer; cancer subtypes; consensus clustering; therapy resistance; MSI; CIMP; cetuximab; serrated pathway; POOR-PROGNOSIS; EXPRESSION; CETUXIMAB; COLON;

D O I：

10.4161/cc.27769

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently we published two independent studies describing novel gene expression-based classifications of colorectal cancer (CRC). Notably, each study stratified CRC into a different number of subtypes: one reported 3 subtypes, whereas the second highlighted 5. Given that each ascribed clinical significance, distinctive biology, and therapeutic prognosis to the different subtypes, we sought to reconcile this apparent incongruity in subtype stratification of CRC, and to interrelate the results. To do so, we each evaluated the other's data sets and analytical methods and discovered that the subtypes and their classifiers are, in fact, clearly related to each other; indeed, the 5 subtype outcomes can be coalesced into the same three. In addition to presenting this clarification, we briefly discuss how both classification methods can be viewed within the broader literature on CRC subtypes, and potentially applied.

引用

页码：353 / 357

页数：5

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