The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein

被引：126
作者：
Horvath, CM [1 ]
Darnell, JE [1 ]
机构：
[1] ROCKEFELLER UNIV,MOLEC CELL BIOL LAB,NEW YORK,NY 10021
来源：
JOURNAL OF VIROLOGY | 1996年 / 70卷 / 01期
关键词：
D O I：
10.1128/JVI.70.1.647-650.1996
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Both of the latent transcription factors activated by alpha interferon or gamma interferon contain the Stat1 protein. The role of Stat1 in virus interference mediated by interferons was directly examined by using cultured cells expressing Stat1 protein and its variants. In the absence of Stat1, no antiviral state is established. Full complementation of the antiviral state requires full-length Stat1 which is phosphorylated on both tyrosine 701 and serine 727. The closely related signal transducer and activator of transcription protein Stat3 cannot substitute for the antiviral properties of Stat1.
引用
收藏
页码：647 / 650
页数：4
相关论文
共 37 条
  • [1] MOLECULAR-CLONING OF APRF, A NOVEL IFN-STIMULATED GENE FACTOR-3 P91-RELATED TRANSCRIPTION FACTOR INVOLVED IN THE GP130-MEDIATED SIGNALING PATHWAY
    AKIRA, S
    NISHIO, Y
    INOUE, M
    WANG, XJ
    WEI, S
    MATSUSAKA, T
    YOSHIDA, K
    SUDO, T
    NARUTO, M
    KISHIMOTO, T
    [J]. CELL, 1994, 77 (01) : 63 - 71
  • [2] PKR - PROPOSED NOMENCLATURE FOR THE RNA-DEPENDENT PROTEIN-KINASE INDUCED BY INTERFERON
    CLEMENS, MJ
    HERSHEY, JWB
    HOVANESSIAN, AC
    JACOBS, BC
    KATZE, MG
    KAUFMAN, RJ
    LENGYEL, P
    SAMUEL, CE
    SEN, GC
    WILLIAMS, BRG
    [J]. JOURNAL OF INTERFERON RESEARCH, 1993, 13 (03): : 241 - 241
  • [3] JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS
    DARNELL, JE
    KERR, IM
    STARK, GR
    [J]. SCIENCE, 1994, 264 (5164) : 1415 - 1421
  • [4] Friedman R.M., 1981, Interferons: a primer
  • [5] THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION
    FU, XY
    SCHINDLER, C
    IMPROTA, T
    AEBERSOLD, R
    DARNELL, JE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) : 7840 - 7843
  • [6] ISGF3, THE TRANSCRIPTIONAL ACTIVATOR INDUCED BY INTERFERON-ALPHA, CONSISTS OF MULTIPLE INTERACTING POLYPEPTIDE-CHAINS
    FU, XY
    KESSLER, DS
    VEALS, SA
    LEVY, DE
    DARNELL, JE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) : 8555 - 8559
  • [7] A MAJOR ROLE FOR THE PROTEIN-TYROSINE KINASE JAK1 IN THE JAK/STAT SIGNAL-TRANSDUCTION PATHWAY IN RESPONSE TO INTERLEUKIN-6
    GUSCHIN, D
    ROGERS, N
    BRISCOE, J
    WITTHUHN, B
    WATLING, D
    HORN, F
    PELLEGRINI, S
    YASUKAWA, K
    HEINRICH, P
    STARK, GR
    IHLE, JN
    KERR, IM
    [J]. EMBO JOURNAL, 1995, 14 (07) : 1421 - 1429
  • [8] INTERFERON-INDUCED PROTEINS - IDENTIFICATION OF MX PROTEINS IN VARIOUS MAMMALIAN-SPECIES
    HORISBERGER, MA
    GUNST, MC
    [J]. VIROLOGY, 1991, 180 (01) : 185 - 190
  • [9] CLONING AND SEQUENCE ANALYSES OF CDNAS FOR INTERFERON-INDUCED AND VIRUS-INDUCED HUMAN MX PROTEINS REVEAL THAT THEY CONTAIN PUTATIVE GUANINE NUCLEOTIDE-BINDING SITES - FUNCTIONAL-STUDY OF THE CORRESPONDING GENE PROMOTER
    HORISBERGER, MA
    MCMASTER, GK
    ZELLER, H
    WATHELET, MG
    DELLIS, J
    CONTENT, J
    [J]. JOURNAL OF VIROLOGY, 1990, 64 (03) : 1171 - 1181
  • [10] A STAT PROTEIN DOMAIN THAT DETERMINES DNA-SEQUENCE RECOGNITION SUGGESTS A NOVEL DNA-BINDING DOMAIN
    HORVATH, CM
    WEN, ZL
    DARNELL, JE
    [J]. GENES & DEVELOPMENT, 1995, 9 (08) : 984 - 994
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