Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

被引：16

作者：

Montgomery, Justin I. ^{[1
]}

Toogood, Peter L. ^{[1
]}

Hutchings, Kim M. ^{[1
]}

Liu, Jia ^{[1
]}

Narasimhan, Lakshmi ^{[1
]}

Braden, Timothy ^{[1
]}

Dermyer, Michael R. ^{[1
]}

Kulynych, Angela D. ^{[1
]}

Smith, Yvonne D. ^{[1
]}

Warmus, Joseph S. ^{[1
]}

Taylor, Clarke ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Michigan Labs, Ann Arbor, MI 48105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Phenylalanyl-tRNA synthetase; PheRS; FRS; Aminoacyl-tRNA synthetase; Benzyl phenyl ether; Antibacterial; SAR; POTENT; SERIES; AGENTS;

D O I：

10.1016/j.bmcl.2008.12.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzyl phenyl ethers (BPEs) is described that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase. The synthesis, SAR, and select ADMET data are provided. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：665 / 669

页数：5

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