A left-handed 9-helix in γ-peptides:: Synthesis and conformational studies of oligomers with dipeptide repeats of C-linked carbo-γ4-amino acids and γ-aminobutyric acid

被引：44

作者：

Sharma, Gangavaram V. M.

Jayaprakash, Pagadala

Narsimulu, Kongari

Sankar, Ampapathi Ravi

Reddy, Kondreddy Ravinder

Krishna, Palakodety Radha

Kunwar, Ajit C.

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 3, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Ctr Nucl Magnet Resonance, Hyderabad 500007, Andhra Pradesh, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 18期

关键词：

amino acids; aminobutyric acid; conformation analysis; helical structures; peptides;

D O I：

10.1002/anie.200504380

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A rare twist: A new class of mixed γ-peptides, derived from dipeptide repeats with alternating C-linked carbo- γ4-amino acids and γ-aminobutyric acid have shown the presence of left-handed 9-helices in solution with CDCl3 (see superimposition of 15 minimum-energy structures of a hexapeptide). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2944 / 2947

页数：4

共 9 条

[1] Synthesis of new 1,2-dideoxy C-linked carbo-β-amino acids and α/β-peptides with 11/9-helix, helix-turn and helix-turn-helix structures
Adepu, Ramesh
Kanakaraju, Marumudi
Chandramouli, Nagula
Reddy, Purushotham P.
Sharma, Gangavaram V. M.
Sarma, Akella V. S.
Kunwar, Ajit C.
TETRAHEDRON, 2018, 74 (42) : 6095 - 6106
[2] Left-handed helical twists in "mixed peptides derived from alternating C-linked carbo-β3-amino acids and β-hGly units
Sharma, GVM
Reddy, KR
Krishna, PR
Sankar, AR
Jayaprakash, P
Jagannadh, B
Kunwar, AC
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (30) : 3961 - 3965
[3] Synthesis and conformational studies of peptides from new C-linked carbo-β-amino acids (β-Caas) with anomeric methylamino- and difluorophenyl moieties
Sharma, Gangavaram V. M.
Subash, Velaparthi
Reddy, Nelli Yella
Narsimulu, Kongari
Ravi, Rapolu
Jadhav, Vivekanand B.
Murthy, Upadhyayula S. N.
Kishore, Kankipati Hara
Kunwar, Ajit C.
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (22) : 4142 - 4156
[4] 9/11 mixed helices in α/β peptides derived from C-linked carbo-β-amino acid and L-ala repeats
Sharma, GVM
Nagendar, P
Jayaprakash, P
Krishna, PR
Ramakrishna, KVS
Kunwar, AC
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (36) : 5878 - 5882
[5] The stereoselective synthesis of C-linked 4′-deoxy aza-disaccharides from C-linked carbo-β-amino acids
Sharma, GVM
Pendem, N
Reddy, KR
Krishna, PR
Narsimulu, K
Kunwar, AC
TETRAHEDRON LETTERS, 2004, 45 (48) : 8807 - 8810
[6] Synthesis of C-linked carbo-β2-amino acids and β2-peptides: design of new motifs for left-handed 12/10-and 10/12-mixed helices
Sharma, Gangavaram V. M.
Reddy, Nelli Yella
Ravi, Rapolu
Sreenivas, Bommagani
Sridhar, Gattu
Chatterjee, Deepak
Kunwar, Ajit C.
Hofmann, Hans-Joerg
ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (46) : 9191 - 9203
[7] Synthesis of β-Peptides with β-Helices from New C-Linked Carbo-β-Amino Acids: Study on the Impact of Carbohydrate Side Chains
Sharma, Gangavaram V. M.
Rao, Kota Sudhakar
Ravi, Rapolu
Narsimulu, Kongari
Nagendar, Pendem
Chandramouli, Chirutha
Kumar, Singarapu Kiran
Kunwar, Ajit C.
CHEMISTRY-AN ASIAN JOURNAL, 2009, 4 (01) : 181 - 193
[8] De novo design and synthesis of helix-turn-helix structure from short and robust mixed helices derived from C-linked carbo-β-amino acids
Sharma, Gangavaram V. M.
Subash, Velaparthi
Narsimulu, Kongari
Sankar, Ampapathi Ravi
Kunwar, Ajit C.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (48) : 8207 - 8210
[9] Theoretical and Experimental Studies on α/ε-Hybrid Peptides: Design of a 14/12-Helix from Peptides with Alternating (S)-C-Linked Carbo-ε-amino Acid [(S)-ε-Caa(x)] and L-Ala
Sharma, Gangavaram V. M.
Babu, Bommagani Shoban
Chatterjee, Deepak
Ramakrishna, Kallaganti V. S.
Kunwar, Ajit C.
Schramm, Peter
Hofmann, Hans-Joerg
JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (17): : 6703 - 6713

← 1 →