Accumulated cytokines in stored autologous blood do not cause febrile nonhemolytic transfusion reactions

被引：4

作者：

Tasaki, Tetsunori ^{[1
,2
]}

Gotoh, Kenji ^{[2
]}

Fujii, Kieko ^{[2
]}

Sasaki, Sakiko ^{[2
]}

Satoh, Shyukuko ^{[2
]}

Takadate, Junko ^{[2
]}

Otsubo, Hiroko ^{[1
]}

Hoshi, Yasutaka ^{[1
]}

机构：

[1] Tokyo Jikei Univ Hosp, Blood Transfus Serv, Minato Ku, Tokyo 1058471, Japan

[2] Iwate Med Univ, Dept Lab Med, Morioka, Iwate, Japan

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2008年 / 39卷 / 01期

关键词：

autologous blood transfusion; febrile not hemolytic transfusion reaction; cytokine;

D O I：

10.1016/j.transci.2008.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Accumulated inflammatory cytokines are considered to be a cause of febrile nonhemolytic transfusion reactions (FNHTRs) of platelet transfusions. Inflammatory cytokines have been found in red cell components stored at 4 degrees C; however, their relationship to FNHTRs has not been clearly demonstrated following red cell transfusions. We measured cytokine levels in stored blood, and determined whether inflammatory marker concentrations were elevated in subjects infused with autologous blood stored for 5 weeks. In conclusion, cytokines accumulated in blood stored at 4 degrees C, but their increases were small. No changes were seen in recipients' inflammatory markers after blood transfusion. Our results indicate that cytokines in stored autologous blood are not responsible for FNHTRs. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：15 / 19

页数：5

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