Synthesis and release behavior of methotrexate from Fe3O4/PLA-PEG core/shell nanoparticles with high saturation magnetization

被引：19

作者：

Chen, Fenghua ^{[1
]}

Zhao, Taonan ^{[1
]}

Chen, Qingtao ^{[1
]}

Han, Lifeng ^{[1
]}

Fang, Shaoming ^{[1
]}

Chen, Zhijun ^{[1
]}

机构：

[1] Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou 450002, Peoples R China

来源：

MATERIALS LETTERS | 2013年 / 108卷

基金：

中国国家自然科学基金;

关键词：

Magnetic materials; Poly(lactide); Polyethylene glycol; Nanocomposites; Drug delivery; DRUG-DELIVERY; NANOCARRIERS; MAGNETITE;

D O I：

10.1016/j.matlet.2013.06.108

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A magnetic targeted drug delivery system with a high Ms value was prepared based on Fe3O4/PLA core/shell nanoparticles for the controlled release methotrexate (MTX). To endow the carrier with hydrophilicity and biocompatibility, an effective surface modification method to graft polyethylene glycol (PEG) was also proposed. The obtained nanocomposites were characterized by TEM, FTIR, XRD, and VSM. The MTX-loading efficiency and drug release behavior of the system were determined by UV-vis spectrometer. The results showed that the MTX displayed a pH-dependent releasing behavior and the existence of PEG would slow down the release rate. Additionally, a cell viability assay was also carried out to evaluate the biocompatibility of Fe3O4/PLA-PEG and the anticancer activities of prepared Fe3O4/PLA-PEG-MTX. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：179 / 182

页数：4

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