Antigens for cancer immunotherapy

被引：127
作者：
Neller, Michelle A. [1 ,2 ]
Lopez, J. Alejandro [1 ,2 ,3 ]
Schmidt, Christopher W. [1 ]
机构：
[1] Queensland Inst Med Res, Brisbane, Qld 4029, Australia
[2] Univ Queensland, Sch Med, Herston, Qld 4006, Australia
[3] Griffith Univ, Sch Biomol & Phys Sci, Nathan, Qld 4111, Australia
来源：
SEMINARS IN IMMUNOLOGY | 2008年 / 20卷 / 05期
基金：
英国医学研究理事会;
关键词：
Cancer; Immunotherapy; Antigen; Tolerance; Clinical trial;
D O I：
10.1016/j.smim.2008.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Progress in tumor immunology has not been translated to effective immunotherapies for cancer. Most of the current effort in basic and clinical research concentrates on generating effective immune responses against model or well characterized antigens, yet vaccines targeting defined antigens have been less clinically successful than those based on whole tumor cells or their extracts. This review considers characteristics of proteins that determine how effectively they might serve as targets of immune control, and how different sources of antigens have fared in clinical trials. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：286 / 295
页数：10
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