Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an) Cl-2(2)] (1), [Pt(pa)(2)Cl-2] (2) and [Pt(aph)(2)Cl-2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI-MS and NMR), and tested against selected Gram(+) and Gram(-) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 A degrees C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(-) bacteria.