Metal-Free Generation of Acyl Radical via Photoinduced Single- Electron Transfer from Lewis Base to Acyl Chloride

被引:21
作者
Bao, Lei [1 ]
Wang, Zhi-Xiang [1 ]
Chen, Xiang-Yu [1 ]
机构
[1] Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China
基金
中国国家自然科学基金;
关键词
LIGHT; AROYLATION; ACTIVATION; CATALYSIS;
D O I
10.1021/acs.orglett.2c03339
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We herein describe a simple approach for generating acyl radical from acyl chloride via photoinduced single-electron transfer. It has been demonstrated that the generated acyl radicals could react with various substrates, including isocyanides, meth-acrylamides, alkenes, alkynes, and enynes, to afford diverse heterocycles (>10 classes). Mechanistic analyses show that a photoactive charge transfer complex between acyl chloride and a Lewis base additive is involved in enabling the photogeneration of the acyl radical. The study exemplifies a new and simple method of photoactivation of carbonyl compounds.
引用
收藏
页码:8223 / 8227
页数:5
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