Long-term Observation of Osteomalacia Caused by Adefovir-Induced Fanconi's Syndrome

被引：2

作者：

Terasaka, Tomohiro ^{[1
]}

Ueta, Eijiro ^{[1
]}

Ebara, Hirotaka ^{[1
]}

Waseda, Koichi ^{[1
]}

Hanayama, Yoshihisa ^{[1
]}

Takaki, Akinobu ^{[2
]}

Kawabata, Tomoko ^{[3
]}

Sugiyama, Hitoshi ^{[3
]}

Hidani, Ko ^{[4
]}

Otsuka, Fumio ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Med, Okayama 7008558, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol, Okayama 7008558, Japan

[3] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med & Clin Sci, Okayama 7008558, Japan

[4] Natl Hosp Org Fukuyama Med Ctr, Dept Orthoped, Fukuyama, Hiroshima 7208520, Japan

来源：

ACTA MEDICA OKAYAMA | 2014年 / 68卷 / 01期

关键词：

adefovir dipivoxil (ADV); eldecalcitol; Fanconi's syndrome; hypophosphatemia; osteomalacia; HEPATITIS-B; DIPIVOXIL THERAPY; CIDOFOVIR;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patient's serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconi's syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.

引用

页码：53 / 56

页数：4