Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine

被引：72

作者：

Shibata, H ^{[1
]}

Sakamoto, Y ^{[1
]}

Oka, M ^{[1
]}

Kono, Y ^{[1
]}

机构：

[1] Shimane Univ, Fac Life & Environm Sci, Dept Life Sci & Biotechnol, Matsue, Shimane 6908504, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 07期

关键词：

chlorogenic acid; DNA damage; gastric injury; monochloramine; natural antioxidant;

D O I：

10.1271/bbb.63.1295

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, form I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 mu M. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.

引用

页码：1295 / 1297

页数：3

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