Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine

被引：72

作者：

Shibata, H ^{[1
]}

Sakamoto, Y ^{[1
]}

Oka, M ^{[1
]}

Kono, Y ^{[1
]}

机构：

[1] Shimane Univ, Fac Life & Environm Sci, Dept Life Sci & Biotechnol, Matsue, Shimane 6908504, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 07期

关键词：

chlorogenic acid; DNA damage; gastric injury; monochloramine; natural antioxidant;

D O I：

10.1271/bbb.63.1295

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, form I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 mu M. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.

引用

页码：1295 / 1297

页数：3

共 26 条

[1]

Baik SC, 1996, CANCER RES, V56, P1279

[2] HEMOGLOBIN-GLUTATHIONE RELATIONSHIPS IN TROUT ERYTHROCYTES TREATED WITH MONOCHLORAMINE [J].

BUCKLEY, JA .

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1982, 29 (06) :637-644

[3] HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS [J].

CHANCE, B ;

SIES, H ;

BOVERIS, A .

PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :527-605

[4] NON-VOLATILE MUTAGENS IN DRINKING-WATER - PRODUCTION BY CHLORINATION AND DESTRUCTION BY SULFITE [J].

CHEH, AM ;

SKOCHDOPOLE, J ;

KOSKI, P ;

COLE, L .

SCIENCE, 1980, 207 (4426) :90-92

[5] CHLORINATED URBAN WATER - CAUSE OF DIALYSIS-INDUCED HEMOLYTIC-ANEMIA [J].

EATON, JW ;

KOLPIN, CF ;

SWOFFORD, HS ;

KJELLSTRAND, CM ;

JACOB, HS .

SCIENCE, 1973, 181 (4098) :463-464

[6] EFFECTS OF NEUTROPHIL-DERIVED OXIDANTS ON INTESTINAL PERMEABILITY, ELECTROLYTE TRANSPORT, AND EPITHELIAL-CELL VIABILITY [J].

GRISHAM, MB ;

GAGINELLA, TS ;

VONRITTER, C ;

TAMAI, H ;

BE, RM ;

GRANGER, DN .

INFLAMMATION, 1990, 14 (05) :531-542

[7]

GRISHAM MB, 1984, J BIOL CHEM, V259, P404

[8]

GRISHAM MB, 1984, J BIOL CHEM, V259, P6757

[9]

HARRISON JE, 1976, J BIOL CHEM, V251, P1371

[10] Antioxidant activity of polyphenolics in diets - Rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen [J].

Kono, Y ;

Kobayashi, K ;

Tagawa, S ;

Adachi, K ;

Ueda, A ;

Sawa, Y ;

Shibata, H .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1997, 1335 (03) :335-342

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