PLA Microspheres-Embedded PVA Hydrogels Prepared by Gamma-Irradiation and Freeze-Thaw Methods as Drug Release Carriers

被引：24
作者：
Behnoodfar, Diba [1 ]
Dadbin, Susan [2 ]
Frounchi, Masoud [1 ]
机构：
[1] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran, Iran
[2] Nucl Sci & Res Inst, Radiat Applicat Res Sch, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2013年 / 62卷 / 01期
关键词：
Drug delivery; freeze-thaw; gamma irradiation; PLA microspheres; PVA hydrogel; POLY(VINYL ALCOHOL); IN-VITRO; FTIR;
D O I：
10.1080/00914037.2011.641648
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A drug delivery system based on poly (vinyl alcohol) (PVA) hydrogels containing ibuprofen-loaded poly (lactic acid) (PLA) microspheres was developed to improve the release kinetics of this model drug. Gamma-irradiation and freeze-thawing were applied to prepare poly (vinyl alcohol) hydrogels. Properties and morphology of these composite hydrogels were investigated using FTIR, DSC, and SEM. In vitro release indicated that entrapment of the microspheres into the PVA hydrogels causes a reduction in both the release rate and the initial burst effect. PLA microspheres entrapped into the PVA hydrogels showed more suitable controlled release kinetics for drug delivery.
引用
收藏
页码：28 / 33
页数：6
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