Compactibility and compressibility studies of Assam Bora rice starch

被引:20
作者
Ahmad, Mohammad Zaki [2 ]
Akhter, Sohail [1 ]
Anwar, Mohammed [1 ]
Rahman, Mahfoozur [2 ]
Siddiqui, Mohammad Ahsan [1 ]
Ahmad, Farhan Jalees [1 ]
机构
[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut, New Delhi 62, India
[2] Dreamz Coll Pharm, Khilra Meramesit 175036, Mandi, India
关键词
Assam Bora rice starch; Tableting properties; Direct compression; Lubricant sensitivity; Heckel analysis; Kawakita plot; PLASMA-VOLUME EXPANDER; MICROCRYSTALLINE CELLULOSE; PHARMACEUTICAL POWDERS; TABLET; PARACETAMOL; VEHICLE; DESIGN;
D O I
10.1016/j.powtec.2012.03.004
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
A comparison study was made on the powder flow characteristics, tableting properties of experimental Assam Bora rice starch, obtained from the variety Aghuni Bora of Oryza sativa and the mechanical properties of tablets made up of it with those of official Starch 1500 (R). The influences of physical and geometrical properties of both the starch were evaluated with regards to their compression properties. It has been found that Assam Bora rice starch reflects better physical characteristics such as higher bulk and tap densities, less porosity, better powder packing ability, minimum lubricant sensitivity, large surface area and improved flowability. Apart from that the mechanical properties, such as toughness and Young's modulus of Assam flora rice starch were also compared with that of Starch 1500 (R). It has been also brought into result that compactibility of Assam flora rice starch was not affected by the blending time. Further compaction properties of the experimental starch were evaluated by using Kawakita and Heckel equations and compared well with those of Starch 1500 (R). The result obtained shows that it mainly deforms by plastic deformation. Their onset of plastic deformation and strain rate sensitivity as compared to that of Starch 1500 (R) demonstrates its potential use as a direct compression filler-binders. (C) 2012 Elsevier B.V. All rights reserved,
引用
收藏
页码:281 / 286
页数:6
相关论文
共 27 条
  • [1] Ahmad MZ, 2012, CURR DRUG DELIV, V9, P105
  • [2] In vitro and in vivo evaluation of Assam Bora rice starch-based bioadhesive microsphere as a drug carrier for colon targeting
    Ahmad, Mohammad Zaki
    Akhter, Sohail
    Ahmad, Iqbal
    Singh, Anjali
    Anwar, Mohammad
    Shamim, Mohammad
    Ahmad, Farhan Jalees
    [J]. EXPERT OPINION ON DRUG DELIVERY, 2012, 9 (02) : 141 - 149
  • [3] Ahmad MZ, 2011, CURR DRUG DELIV, V8, P575
  • [4] Ahmad Mohammad Zaki, 2010, Current Drug Delivery, V7, P162
  • [5] Armstrong N.A., 1972, J PHARM PHARMACOL, V24, P135
  • [6] TENSILE STRENGTHS OF PARACETAMOL AND AVICEL POWDERS AND THEIR MIXTURES
    BANGUDU, AB
    PILPEL, N
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1984, 36 (11) : 717 - 722
  • [7] Bhattacharya Ashokanshu, 2010, Current Drug Delivery, V7, P436, DOI 10.2174/156720110793566209
  • [8] NATIVE STARCH IN TABLET FORMULATIONS - PROPERTIES ON COMPACTION
    BOS, CE
    BOLHUIS, GK
    VANDOORNE, H
    LERK, CF
    [J]. PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1987, 9 (05) : 274 - 282
  • [9] Chowhan C.T., 1980, INT J PHARMACEUT, V5, P139
  • [10] Gupta P., 2006, Excipient Development for Pharmaceutical, Biotechnology and Drug Delivery Systems, P109