Collagen-Polymer Guidance of Vessel Network Formation and Stabilization by Endothelial Colony Forming Cells In Vitro

被引：31
|
作者：
Whittington, Catherine F. [1 ]
Yoder, Mervin C. [2 ,3 ,4 ]
Voytik-Harbin, Sherry L. [1 ,5 ]
机构：
[1] Purdue Univ, Coll Engn, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA
[2] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA
[4] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA
[5] Purdue Univ, Sch Vet Med, Dept Basic Med Sci, W Lafayette, IN 47907 USA
来源：
MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 09期
基金：
美国国家科学基金会;
关键词：
endothelial colony forming cells; microstructure; oligomers; type I collagen; vasculogenesis; MESENCHYMAL STEM-CELLS; LYSYL OXIDASE; CAPILLARY MORPHOGENESIS; PROGENITOR CELLS; LUMEN FORMATION; GROWTH-FACTOR; EXTRACELLULAR MATRICES; MECHANICAL-PROPERTIES; SIGNAL-TRANSDUCTION; MOLECULAR-BASIS;
D O I：
10.1002/mabi.201300128
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vessel morphogenesis is vital to regenerative medicine strategies. Here, collagen polymers, specified by intermolecular cross-link composition, are used to independently vary microstructure (fibril density, interfibril branching) and physical properties (stiffness) to guide 3D vessel network formation by endothelial colony forming cells (ECFC) in vitro. Increasing stiffness, by modulation of fibril density or interfibril branching, increases vessel diameter, length and branching. Oligomer matrices also induce vessel stabilization via type IV collagen deposition. This work shows that ECFC vessel formation depends on the interplay of collagen microstructure and physical properties and names oligomers and intermolecular cross-links as key design parameters for vascular-inductive matrices.
引用
收藏
页码：1135 / 1149
页数：15
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